The human preterm brain is particularly susceptible to cerebral white matter injury (WMI) that
disrupts the normal progression of developmental myelination. Advances in the care of …

Hypoxic-ischemic and traumatic brain injuries are leading causes of long-term mortality and
disability in infants and children. Although several preclinical models using rodents of …

Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …

Despite the large number of immunomodulatory or immunosuppressive treatments available
to treat relapsing–remitting multiple sclerosis (MS), treatment of the progressive phase of the …

Oligodendrogenesis occurs during early postnatal development, coincident with
neurogenesis and synaptogenesis, raising the possibility that microglia-dependent pruning …

Progesterone is commonly considered as a female reproductive hormone and is well-known
for its role in pregnancy. It is less well appreciated that progesterone and its metabolite …

Within the substantially different time scales characterizing human and rodent brain
development, key developmental processes are remarkably preserved. Shared processes …

As the sheer number of transgenic mice strains grow and rodent models of pediatric disease
increase, there is an expanding need for a comprehensive, standardized battery of neonatal …

Demyelination is the hallmark of numerous neurodegenerative conditions, including multiple
sclerosis. Oligodendrocyte progenitors (OPCs), which normally mature into myelin-forming …

In the past 2 decades, it has become evident that individuals born with congenital heart
disease (CHD) are at risk of developing life-long neurological deficits. Multifactorial risk …