Background Recent trials of anti-amyloid-β (Aβ) monoclonal antibodies, including
lecanemab and donanemab, in early Alzheimer disease (AD) showed that these drugs have …

Neurodegeneration is preeminent in many neurological diseases, and still a major burden
we fail to manage in patient's care. Its pathogenesis is complicated, intricate, and far from …

The identification of neuroinflammation as a critical factor in Alzheimer's disease (AD) has
expanded the focus of research beyond amyloid-β and tau pathology. The …

Background Plasma biomarkers are preferable to invasive and expensive diagnostic tools,
such as neuroimaging and lumbar puncture that are gold standard in the clinical …

More than a century after the first description of Alzheimer's disease (AD), the road to a cure
for this complex and heterogeneous neurodegenerative disorder has been paved by …

Despite the presence of significant Alzheimer's disease (AD) pathology, characterized by
amyloid β (Aβ) plaques and phosphorylated tau (pTau) tangles, some cognitively normal …

El objetivo general de esta Tesis se ha centrado en proporcionar: a) una prueba del
principio del mecanismo de acción de la aféresis selectiva yb) una prueba de concepto de …