Protein phosphorylation is a major control mechanism of a wide range of physiological
processes and plays an important role in cardiac pathophysiology. Serine/threonine protein …

Mass spectrometry-based proteomics is a sophisticated identification tool specializing in
portraying protein dynamics at a molecular level. Proteomics provides biologists with a …

Background—Cardiac hypertrophy and subsequent heart failure triggered by chronic
hypertension represent major challenges for cardiovascular research. Beyond …

Background—After myocardial ischemia, extracellular matrix (ECM) deposition occurs at the
site of the focal injury and at the border region. Methods and Results—We have applied a …

Abdominal aortic aneurysms (AAA) are characterized by pathological remodeling of the
aortic extracellular matrix (ECM). However, besides the well-characterized elastolysis and …

Heart failure (HF) is a leading cause of morbidity and mortality worldwide and is most often
precipitated by myocardial infarction. However, the molecular changes driving cardiac …

Background: Biased agonism of the angiotensin II receptor is known to promote cardiac
contractility. Our laboratory indicated that these effects may be attributable to changes at the …

Homeostasis of cardiac function requires significant adjustments in sarcomeric protein
phosphorylation. The existence of unique peptides in cardiac sarcomeres, which are …

Activation of adrenergic receptors (AR) represents the primary mechanism to increase
cardiac performance under stress. Activated βAR couple to Gs protein, leading to adenylyl …

Reversible protein phosphorylation is central to a variety of cardiac processes including
excitation-contraction coupling, Ca 2+ handling, cell metabolism, myofilament regulation …