Serotonin reuptake inhibitor antidepressants, including selective serotonin reuptake
inhibitors (SSRIs; ie, citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and …

Cytochromes P450 are members of a superfamily of hemoproteins that catalyze a variety of
oxidative reactions in the metabolism of endogenous and exogenous hydrophobic …

Background Plasmodium vivax malaria is characterized by relapses arising from the
hypnozoite stages in the liver. The only currently registered drug for radical treatment to …

The CYP2D6 gene encodes for an enzyme that is involved in the metabolism of more than
25% of all medications, including many opioids and antiemetics. It may contribute to the risk …

Estrogen-receptor positive breast cancer accounts for 75% of diagnosed breast cancers
worldwide. There are currently two major options for adjuvant treatment: tamoxifen and …

Nowadays antidepressants are still administrated by a trial and error principle and a
substantial proportion of patients does not benefit from treatment or suffers from significant …

Molecular autopsy is a very important tool in forensic toxicology. However, many
determinants, such as co-medication and physiological parameters, should be considered …

Approximately 25% of clinically important drugs and numerous environmental carcinogens
are metabolised by CYP2D6. Variation in the CYP2D6 gene and concomitant use of …

Abstract In 2010–2013, 29 fatal intoxications related to the designer drug
paramethoxymethamphetamine (PMMA, 4-methoxymethamphetamine) occurred in Norway …

The cytochrome P450 family is composed of hemeproteins involved in the metabolic
transformation of endogenous and exogenous substances. The CYP2D6 enzyme is …