State of the science on mild cognitive impairment (MCI)
ND Anderson - CNS spectrums, 2019 - cambridge.org
Mild cognitive impairment (MCI) represents a transitional stage between healthy aging and
dementia, and affects 10–15% of the population over the age of 65. The failure of drug trials …
dementia, and affects 10–15% of the population over the age of 65. The failure of drug trials …
Sex steroids and the female brain across the lifespan: insights into risk of depression and Alzheimer's disease
Despite widespread sex differences in prevalence and presentation of numerous illnesses
affecting the human brain, there has been little focus on the effect of endocrine ageing. Most …
affecting the human brain, there has been little focus on the effect of endocrine ageing. Most …
Entorhinal tau pathology, episodic memory decline, and neurodegeneration in aging
The medial temporal lobe (MTL) is an early site of tau accumulation and MTL dysfunction
may underlie episodic-memory decline in aging and dementia. Postmortem data indicate …
may underlie episodic-memory decline in aging and dementia. Postmortem data indicate …
Differentiation of mild cognitive impairment using an entorhinal cortex-based test of virtual reality navigation
D Howett, A Castegnaro, K Krzywicka, J Hagman… - Brain, 2019 - academic.oup.com
The entorhinal cortex is one of the first regions to exhibit neurodegeneration in Alzheimer's
disease, and as such identification of entorhinal cortex dysfunction may aid detection of the …
disease, and as such identification of entorhinal cortex dysfunction may aid detection of the …
Alzheimer's pathology targets distinct memory networks in the ageing brain
Alzheimer's disease researchers have been intrigued by the selective regional vulnerability
of the brain to amyloid-β plaques and tau neurofibrillary tangles. Post-mortem studies …
of the brain to amyloid-β plaques and tau neurofibrillary tangles. Post-mortem studies …
[HTML][HTML] Functional imbalance of anterolateral entorhinal cortex and hippocampal dentate/CA3 underlies age-related object pattern separation deficits
ZM Reagh, JA Noche, NJ Tustison, D Delisle… - Neuron, 2018 - cell.com
The entorhinal cortex (EC) is among the earliest brain areas to deteriorate in Alzheimer's
disease (AD). However, the extent to which functional properties of the EC are altered in the …
disease (AD). However, the extent to which functional properties of the EC are altered in the …
[HTML][HTML] Cortical tau deposition follows patterns of entorhinal functional connectivity in aging
Tau pathology first appears in the transentorhinal and anterolateral entorhinal cortex (alEC)
in the aging brain. The transition to Alzheimer's disease (AD) is hypothesized to involve …
in the aging brain. The transition to Alzheimer's disease (AD) is hypothesized to involve …
[HTML][HTML] Re-emphasizing early Alzheimer's disease pathology starting in select entorhinal neurons, with a special focus on mitophagy
The entorhinal-hippocampal system contains distinct networks subserving declarative
memory. This system is selectively vulnerable to changes of ageing and pathological …
memory. This system is selectively vulnerable to changes of ageing and pathological …
[HTML][HTML] Ultra-high-field 7T MRI reveals changes in human medial temporal lobe volume in female adults during menstrual cycle
Ovarian hormones have substantial effects on the brain, and early menopause has been
associated with increased risk of accelerated brain aging and dementia later in life …
associated with increased risk of accelerated brain aging and dementia later in life …
[HTML][HTML] Age-related functional changes in domain-specific medial temporal lobe pathways
There is now converging evidence from studies in animals and humans that the medial
temporal lobes (MTLs) harbor anatomically distinct processing pathways for object and …
temporal lobes (MTLs) harbor anatomically distinct processing pathways for object and …