Cryptococcus: from environmental saprophyte to global pathogen

RC May, NRH Stone, DL Wiesner, T Bicanic… - Nature Reviews …, 2016 - nature.com
Cryptococcosis is a globally distributed invasive fungal infection that is caused by species
within the genus Cryptococcus which presents substantial therapeutic challenges. Although …

Quorum sensing in fungal species

X Tian, H Ding, W Ke, L Wang - Annual Review of Microbiology, 2021 - annualreviews.org
Quorum sensing (QS) is one of the most studied cell-cell communication mechanisms in
fungi. Research in the last 20 years has explored various fungal QS systems that are …

Fungal biofilms, drug resistance, and recurrent infection

JV Desai, AP Mitchell… - Cold Spring …, 2014 - perspectivesinmedicine.cshlp.org
A biofilm is a surface-associated microbial community. Diverse fungi are capable of biofilm
growth. The significance of this growth form for infection biology is that biofilm formation on …

Lectins as antimicrobial agents

LC Breitenbach Barroso Coelho… - Journal of applied …, 2018 - academic.oup.com
The resistance of micro‐organisms to antimicrobial agents has been a challenge to treat
animal and human infections, and for environmental control. Lectins are natural proteins and …

Role of quorum sensing and chemical communication in fungal biotechnology and pathogenesis

J Barriuso, DA Hogan, T Keshavarz… - FEMS microbiology …, 2018 - academic.oup.com
Microbial cells do not live in isolation in their environment, but rather they communicate with
each other using chemical signals. This sophisticated mode of cell-to-cell signalling, known …

The structural unit of melanin in the cell wall of the fungal pathogen Cryptococcus neoformans

E Camacho, R Vij, C Chrissian… - Journal of Biological …, 2019 - ASBMB
Melanins are synthesized macromolecules that are found in all biological kingdoms. These
pigments have a myriad of roles that range from microbial virulence to key components of …

Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators

B Hommel, L Mukaremera, RJB Cordero… - PLoS …, 2018 - journals.plos.org
The pathogenic fungus Cryptococcus neoformans exhibits morphological changes in cell
size during lung infection, producing both typical size 5 to 7 μm cells and large titan cells (> …

Fungal G-protein-coupled receptors: mediators of pathogenesis and targets for disease control

NA Brown, S Schrevens, P Van Dijck… - Nature Microbiology, 2018 - nature.com
G-protein signalling pathways are involved in sensing the environment, enabling fungi to
coordinate cell function, metabolism and development with their surroundings, thereby …

Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals

N Trevijano-Contador, HC de Oliveira… - PLoS …, 2018 - journals.plos.org
Cryptococcus neoformans is an encapsulated pathogenic yeast that can change the size of
the cells during infection. In particular, this process can occur by enlarging the size of the …

Biofilm Formation by Cryptococcus neoformans

LR Martinez, A Casadevall - Microbial Biofilms, 2015 - Wiley Online Library
Historically, microbiologists have studied microbes that cause infectious diseases by
analyzing microbial cells grown in suspension (planktonic) in the laboratory. This tradition …