There are inherent limitations with traditional methods to study protein behavior or to
determine the constituency of proteins in discrete subcellular compartments. In response to …

Thioredoxin interacting protein (TXNIP) is a metabolism-oxidative-and inflammation-related
marker induced in cardiovascular diseases and is believed to represent a possible link …

Retinitis pigmentosa (RP) is an inherited retinal disease affecting> 20 million people
worldwide. Loss of daylight vision typically occurs due to the dysfunction/loss of cone …

Retinitis pigmentosa is a blinding disease wherein rod photoreceptors are affected first, due
to the expression of a disease gene, leading to the loss of dim light vision. In many cases …

Diabetic Retinopathy (DR) is a major cause of visual dysfunction, yet much remains
unknown regarding the specific molecular events that contribute to diabetes-induced retinal …

Significance: Thioredoxin interacting protein (TXNIP) is a member of the arrestin fold
superfamily with important cellular functions, including cellular transport, mitochondrial …

Significance: Decrypting the cellular response to oxidative stress relies on a comprehensive
understanding of the redox signaling pathways stimulated under oxidizing conditions …

Thioredoxin-interacting protein (TXNIP) is a key player in the endocrine pancreas; it induces
beta cell apoptosis, such that TXNIP deficiency promotes beta cell survival. To study its …

Notch signaling plays a critical role in cell fate decisions in all cell types. Furthermore, gain-
of-function mutations in NOTCH1 have been uncovered in many human cancers. Disruption …

Retinitis pigmentosa (RP) is an inherited retinal disease in which there is a loss of cone-
mediated daylight vision. As there are> 100 disease genes, our goal is to preserve cone …