Filamin A (FLNa) is an actin-binding protein, which participates in the formation of the
cytoskeleton, anchors a variety of proteins in the cytoskeleton and regulates cell adhesion …

RNA is not always a faithful copy of DNA. Advances in tools enabling the interrogation of the
exact RNA sequence have permitted revision of how genetic information is transferred. We …

Atherosclerosis is a chronic inflammatory disease and the major pathological factor of most
cardiovascular diseases, leading to≈ 1/3 of deaths worldwide. Improving local delivery of …

Objective: Macrophages are immune cells, capable to remodel the extracellular matrix,
which can harbor extracellular DNA incorporated into neutrophil extracellular traps (NETs) …

Exploring the immune mechanism of coxsackievirus B3 (CVB3)-induced myocarditis may
provide a promising therapeutic strategy. Here, we investigated the regulatory role of …

Filamin A (FLNA) is a large actin-binding cytoskeletal protein that is important for cell motility
by stabilizing actin networks and integrating them with cell membranes. Interestingly, a C …

Several drug screening campaigns identified Calpeptin as a drug candidate against SARS-
CoV-2. Initially reported to target the viral main protease (Mpro), its moderate activity in Mpro …

Background and aims Fargesin mainly functions in the improvement of lipid metabolism and
the inhibition of inflammation, but the role of fargesin in atherogenesis and the molecular …

The dynamic organization of actin cytoskeleton meshworks relies on multiple actin-binding
proteins endowed with distinct actin-remodeling activities. Filamin A is a large multi-domain …

Calpain is defined as a member of the superfamily of cysteine proteases possessing the
CysPC motif within the gene. Calpain-1 and-2, which are categorized as conventional …