Chronic lymphocytic leukemia and mantle cell lymphoma: crossroads of genetic and microenvironment interactions

XS Puente, P Jares, E Campo - Blood, The Journal of the …, 2018 - ashpublications.org
Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) are 2 well-defined
entities that diverge in their basic pathogenic mechanisms and clinical evolution but they …

Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes

F Nadeu, D Martin-Garcia, G Clot… - Blood, The Journal …, 2020 - ashpublications.org
Mantle cell lymphoma (MCL) is a mature B-cell neoplasm initially driven by CCND1
rearrangement with 2 molecular subtypes, conventional MCL (cMCL) and leukemic non …

Mantle cell lymphoma—a spectrum from indolent to aggressive disease

B Sander, L Quintanilla-Martinez, G Ott, L Xerri, I Kuzu… - Virchows Archiv, 2016 - Springer
Mantle cell lymphoma (MCL) is a distinctive lymphoma type generally characterized by the
presence of CCND1 translocation and overexpression of cyclin D1. MCL usually presents …

Expression of TP53 is associated with the outcome of MCL independent of MIPI and Ki-67 in trials of the European MCL Network

SM Aukema, E Hoster, A Rosenwald… - Blood, The Journal …, 2018 - ashpublications.org
Currently, prediction of time to treatment failure (TTF) and overall survival (OS) in mantle cell
lymphoma (MCL) is based on the clinical factors included in the Mantle Cell Lymphoma …

CCND2 and CCND3 hijack immunoglobulin light-chain enhancers in cyclin D1 mantle cell lymphoma

D Martín-Garcia, A Navarro… - Blood, The Journal …, 2019 - ashpublications.org
Mantle cell lymphoma (MCL) is characterized by the t (11; 14)(q13; q32) translocation
resulting in overexpression of cyclin D1. However, a small subset of cyclin D1− MCL has …

A gene signature that distinguishes conventional and leukemic nonnodal mantle cell lymphoma helps predict outcome

G Clot, P Jares, E Gine, A Navarro… - Blood, The Journal …, 2018 - ashpublications.org
Mantle cell lymphoma (MCL) is an aggressive B-cell malignancy, but some patients have a
very indolent evolution. This heterogeneous course is related, in part, to the different …

SOX11, CD70, and Treg cells configure the tumor immune microenvironment of aggressive mantle cell lymphoma

P Balsas, L Veloza, G Clot… - Blood, The Journal …, 2021 - ashpublications.org
Mantle cell lymphoma (MCL) is a mature B-cell neoplasm with a heterogeneous clinical and
biological behavior. SOX11 oncogenic expression contributes to the aggressiveness of …

SOX11: friend or foe in tumor prevention and carcinogenesis?

Z Yang, S Jiang, C Lu, T Ji, W Yang… - … in medical oncology, 2019 - journals.sagepub.com
Sex-determining region Y-related high-mobility-group box transcription factor 11 (SOX11) is
an essential member of the SOX transcription factors and has been highlighted as an …

SOX11, a key oncogenic factor in mantle cell lymphoma

R Beekman, V Amador, E Campo - Current Opinion in Hematology, 2018 - journals.lww.com
SOX11 is a relevant element in the pathogenesis of MCL and has been instrumental to
identify two distinct clinicobiological subtypes of this tumor. Further studies should clarify the …

Recent advances in intestinal lymphomas

PG Foukas, L de Leval - Histopathology, 2015 - Wiley Online Library
A large variety of lymphoma types may develop as primary intestinal neoplasms in the small
intestines or, less often, in the colorectum. Among these are a few entities such as …