Tryptophan is an essential amino acid critical for protein synthesis in humans that has
emerged as a key player in the microbiota-gut-brain axis. It is the only precursor for the …

The brain-gut axis is a bidirectional communication system between the central nervous
system and the gastrointestinal tract. Serotonin functions as a key neurotransmitter at both …

Functional bowel disorders are highly prevalent disorders found worldwide. These disorders
have the potential to affect all members of society, regardless of age, sex, race, creed, color …

Abstract Serotonin (5-HT) has been recognized for decades as an important signalling
molecule in the gut, but it is still revealing its secrets. Novel gastrointestinal functions of 5-HT …

Objectives: Irritable bowel syndrome (IBS) is viewed as a diagnosis of exclusion by most
providers. The aim of our study was to perform a systematic review and meta-analysis to …

Rationale Early life stress has been implicated in many psychiatric disorders ranging from
depression to anxiety. Maternal separation in rodents is a well-studied model of early life …

We need to look beyond our gut instincts to use information on “simple” intestinal
physiological parameters as they have been presented to us in the past. Here we present a …

Functional gastrointestinal (GI) disorders (FGIDs) result from central and peripheral
mechanisms, cause chronic remitting-relapsing symptoms, and are associated with …

Saccharomyces boulardii (Sb) is a widely used fungal probiotic in treating various digestive
diseases, including irritable bowel syndrome (IBS). However, the specific mechanisms of Sb …

OBJECTIVES: Serotonin (5-hydroxytryptamine, 5-HT) metabolism may be altered in gut
disorders, including in the irritable bowel syndrome (IBS). We assessed in patients with IBS …