Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide-binding (G)
proteins, including the ARF-like (ARL) proteins and SAR1, regulate membrane traffic and …

The Golgi serves as a hub for intracellular membrane traffic in the eukaryotic cell. Transport
within the early secretory pathway, that is within the Golgi and from the Golgi to the …

The obligate intracellular pathogen Chlamydia trachomatis replicates within a membrane-
bound inclusion that acquires host sphingomyelin (SM), a process that is essential for …

Intracellular bacterial pathogens subvert the endocytic bactericidal pathway to form specific
replication-permissive compartments termed pathogen vacuoles or inclusions. To this end …

Abstract Phosphatidylinositol 4-phosphate (PI4P) is a membrane glycerophospholipid and a
major regulator of the characteristic appearance of the Golgi complex as well as its vesicular …

Cell polarity in eukaryotes requires constant sorting, packaging and transport of membrane-
bound cargo within the cell. These processes occur in two sorting hubs: the recycling …

Phosphoinositides are key regulators of a large number of diverse cellular processes that
include membrane trafficking, plasma membrane receptor signaling, cell proliferation, and …

Phosphatidylinositol lipids are signaling molecules involved in nearly all aspects of cellular
regulation. Production of phosphatidylinositol 4-phosphate (PI4P) has long been recognized …

To form protrusions like neurites, cells must coordinate their induction and growth. The first
requires cytoskeletal rearrangements at the plasma membrane (PM), the second requires …

Proteins to be secreted are transported from the endoplasmic reticulum (ER) to the Golgi
apparatus. The transport of these proteins requires the localization and activity of proteins …