Cancer is a disease with complex pathological process. Current chemotherapy faces
problems such as lack of specificity, cytotoxicity, induction of multi-drug resistance and stem …

Abstract The international American Joint Committee on Cancer/Union for International
Cancer Control (AJCC/UICC) tumour-node-metastasis (TNM) staging system provides the …

Systemic inflammation markers have been linked to increased cancer risk and mortality in a
number of studies. However, few studies have estimated pre-diagnostic associations of …

Antitumoral immunity requires organized, spatially nuanced interactions between
components of the immune tumor microenvironment (iTME). Understanding this coordinated …

Immunotherapy is revolutionizing the clinical management of multiple tumors. However, only
a fraction of patients with cancer responds to immunotherapy, and currently available …

Tumors evolve in close interaction with their microenvironment, which encompasses a
continual tension between the developing tumor and the host immune system. Clinical trials …

The progression of cancer involves a critical step in which malignant cells escape from
control by the immune system. Antineoplastic agents are particularly efficient when they …

Background Understanding the interactions between tumor and the host immune system is
critical to finding prognostic biomarkers, reducing drug resistance, and developing new …

Assessment of the immune response to tumors is growing in importance as the prognostic
implications of this response are increasingly recognized, and as immunotherapies are …

Critical driver genomic events in colorectal cancer have been shown to affect the response
to targeted agents that were initially developed under the'one gene, one drug'paradigm of …