Macrophage polarization: different gene signatures in M1 (LPS+) vs. classically and M2 (LPS–) vs. alternatively activated macrophages
M Orecchioni, Y Ghosheh, AB Pramod… - Frontiers in …, 2019 - frontiersin.org
Macrophages are found in tissues, body cavities, and mucosal surfaces. Most tissue
macrophages are seeded in the early embryo before definitive hematopoiesis is …
macrophages are seeded in the early embryo before definitive hematopoiesis is …
Functional hallmarks of healthy macrophage responses: their regulatory basis and disease relevance
KM Sheu, A Hoffmann - Annual review of immunology, 2022 - annualreviews.org
Macrophages are first responders for the immune system. In this role, they have both effector
functions for neutralizing pathogens and sentinel functions for alerting other immune cells of …
functions for neutralizing pathogens and sentinel functions for alerting other immune cells of …
Hypertension-linked pathophysiological alterations in the gut
Rationale: Sympathetic nervous system control of inflammation plays a central role in
hypertension. The gut receives significant sympathetic innervation, is densely populated …
hypertension. The gut receives significant sympathetic innervation, is densely populated …
HMGB1 in health and disease
R Kang, R Chen, Q Zhang, W Hou, S Wu, L Cao… - Molecular aspects of …, 2014 - Elsevier
Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …
emergence of chromosomal instability, development of unscheduled cell death, skewed …
DAMPs, MAMPs, and NAMPs in plant innate immunity
HW Choi, DF Klessig - BMC plant biology, 2016 - Springer
Background Multicellular organisms have evolved systems/mechanisms to detect various
forms of danger, including attack by microbial pathogens and a variety of pests, as well as …
forms of danger, including attack by microbial pathogens and a variety of pests, as well as …
Targeting the receptor for advanced glycation endproducts (RAGE): a medicinal chemistry perspective
S Bongarzone, V Savickas, F Luzi… - Journal of medicinal …, 2017 - ACS Publications
The receptor for advanced glycation endproducts (RAGE) is an ubiquitous, transmembrane,
immunoglobulin-like receptor that exists in multiple isoforms and binds to a diverse range of …
immunoglobulin-like receptor that exists in multiple isoforms and binds to a diverse range of …
Lipopolysaccharide activates Toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathway and proinflammatory response in human pericytes
I Guijarro-Muñoz, M Compte… - Journal of Biological …, 2014 - ASBMB
Pericytes and mesenchymal stem cells (MSCs) are ontogenically related, and in fact, no
significant phenotypic differences could be observed by flow cytometry. Transcriptome …
significant phenotypic differences could be observed by flow cytometry. Transcriptome …
Danger-associated molecular patterns in Alzheimer's disease
C Venegas, MT Heneka - Journal of Leucocyte Biology, 2017 - academic.oup.com
Pathogen-associated molecular patterns (PAMPs) and endogenous “danger” signals,
known as danger-associated molecular patterns (DAMPs), released from cells alert the …
known as danger-associated molecular patterns (DAMPs), released from cells alert the …
High‐mobility group box‐1 in sterile inflammation
A Tsung, S Tohme, TR Billiar - Journal of internal medicine, 2014 - Wiley Online Library
High‐mobility group box 1 (HMGB 1) was originally defined as a ubiquitous nuclear protein,
but it was later determined that the protein has different roles both inside and outside of …
but it was later determined that the protein has different roles both inside and outside of …
The Janus face of HMGB1 in heart disease: a necessary update
A Raucci, S Di Maggio, F Scavello… - Cellular and Molecular …, 2019 - Springer
High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein involved in transcription
regulation, DNA replication and repair and nucleosome assembly. HMGB1 is passively …
regulation, DNA replication and repair and nucleosome assembly. HMGB1 is passively …