The plasma membrane is a complex fluid where lipids and proteins undergo diffusive motion
critical to biochemical reactions. Through quantitative imaging analyses such as single …

Sphingolipids are structural components in the plasma membranes of eukaryotic cells. Their
metabolism produces bioactive signaling molecules that modulate fundamental cellular …

Kv2. 1 exhibits two distinct forms of localization patterns on the neuronal plasma membrane:
One population is freely diffusive and regulates electrical activity via voltage-dependent K+ …

Dopamine neurotransmission is highly dysregulated by the psychostimulant
methamphetamine, a substrate for the dopamine transporter (DAT). Through interactions …

A broad range of membrane proteins display anomalous diffusion on the cell surface.
Different methods provide evidence for obstructed subdiffusion and diffusion on a fractal …

Junctions between cortical endoplasmic reticulum (cER) and the plasma membrane are a
subtle but ubiquitous feature in mammalian cells; however, very little is known about the …

Potentiation of synaptic strength relies on postsynaptic Ca 2+ signals, modification of
dendritic spine structure, and changes in gene expression. One Ca 2+ signaling pathway …

Endoplasmic reticulum (ER)-plasma membrane (PM) junctions are membrane
microdomains important for communication between the ER and the PM. ER-PM junctions …

Close appositions between the endoplasmic reticulum (ER) and the plasma membrane (PM)
are a general feature of all cells and are abundant in neurons. A function of these …

Active transport and local translation of mRNAs ensure the appropriate spatial organization
of proteins within cells. Recent work has shown that this process is intricately connected to …