Intervertebral disc (IVD) degeneration (IDD) is a multifactorial pathological process
associated with low back pain (LBP). The pathogenesis is complicated, and the main …

Intervertebral disc degeneration (IDD) is a major contributor to back, neck, and radicular
pain. It is related to changes in tissue structure and function, including the breakdown of the …

Intervertebral disc degeneration (IDD) has been considered as the primary pathological
mechanism that underlies low back pain. Understanding the molecular mechanisms …

Background Intervertebral disc degeneration (IDD) is a leading cause of low back pain
(LBP), posing a significant socioeconomic burden. Recent studies highlight the crucial role …

Abstract» Orthopaedics pioneered the expansion of gene therapy beyond its traditional
scope of diseases that are caused by rare single-gene defects. Orthopaedic applications of …

An important mechanism for the development of intervertebral disc degeneration (IDD) is an
imbalance between anti-inflammatory and pro-inflammatory cytokines. Therapeutic and non …

Background Intervertebral disc (IVD) shows aging and degenerative changes earlier than
any other body connective tissue. Its repair and regeneration provide a considerable …

Background: Intervertebral disc degeneration (IDD) is the leading cause of lower back pain,
and an overall understanding of the molecular mechanisms related to IDD is still lacking …

Lower back pain is a leading cause of disability and is one of the reasons for the substantial
socioeconomic burden. The etiology of intervertebral disc (IVD) degeneration is …

Background This study assessed the role and potential mechanism of platelet-rich plasma
(PRP) in the progression of intervertebral disk degeneration (IVDD). Methods Annulus …