Salt and fluid absorption and secretion are two processes that are fundamental to epithelial
function and whole body fluid homeostasis, and as such are tightly regulated in epithelial …

Knowledge on the mechanisms of acid and base secretion in airways has progressed
recently. The aim of this review is to summarize the known mechanisms of airway surface …

The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …

Bicarbonate facilitates mucin unpacking and bacterial killing; however, its transport
mechanisms in the airways are not well understood. cAMP stimulates anion efflux through …

The solute carrier family 4 (SLC4) is an important protein responsible for the transport of
various ions across the cell membrane and mediating diverse physiological functions, such …

Background: Polarized airway epithelial cell cultures modelling Cystic Fibrosis
Transmembrane conductance Regulator (CFTR) defect are crucial for CF and biomedical …

Key points Fluid and HCO3− secretion is essential for all epithelia; aberrant secretion is
associated with several diseases. Carbonic anhydrase XII (CA12) is the key carbonic …

Key points• The mechanisms of anion and fluid transport by airway submucosal glands are
not well understood and may differ from those in surface epithelium.• The Calu‐3 cell line is …

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator
(CFTR), an anion channel providing a major pathway for Cl− and HCO3− efflux across the …

Culture at the air–liquid interface is broadly accepted as necessary for differentiation of
cultured epithelial cells towards an in vivo-like phenotype. However, air–liquid interface …