Ki-67 protein has been widely used as a proliferation marker for human tumor cells for
decades. In recent studies, multiple molecular functions of this large protein have become …

Aurora kinases are serine/threonine kinases essential for the onset and progression of
mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit …

The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

Life depends on cell proliferation and the accurate segregation of chromosomes, which are
mediated by the microtubule (MT)-based mitotic spindle and∼ 200 essential MT-associated …

Chromosome segregation in mammalian oocytes is driven by a microtubule spindle lacking
centrosomes. Here, we analyze centrosome-independent spindle assembly by quantitative …

Error-free chromosome segregation requires stable attachment of sister kinetochores to the
opposite spindle poles (amphitelic attachment). Exactly how amphitelic attachments are …

The conserved Aurora family of protein kinases have emerged as crucial regulators of
mitosis and cytokinesis. Despite their high degree of homology, Aurora A and B have very …

During cell division, microtubules are arranged in a large bipolar structure, the mitotic
spindle, to segregate the duplicated chromosomes. Antiparallel microtubule overlaps in the …

The molecular mechanism responsible that determines cell fate after mitotic slippage is
unclear. Here we investigate the post-mitotic effects of different mitotic aberrations …

The gene encoding the Aurora-A protein kinase is located in the 20q13 breast cancer
amplicon and is also overexpressed in colorectal, pancreatic and gastric tumours. Although …