Hyaluronan–CD44 interaction promotes oncogenic signaling, microRNA functions, chemoresistance, and radiation resistance in cancer stem cells leading to tumor …
LYW Bourguignon, M Shiina, JJ Li - Advances in cancer research, 2014 - Elsevier
Hyaluronan (HA), a major component of the extracellular matrix (ECM), is enriched in many
types of tumors. There is good evidence linking high levels of HA production in human …
types of tumors. There is good evidence linking high levels of HA production in human …
Molecular markers of head and neck squamous cell carcinoma: promising signs in need of prospective evaluation
P Lothaire, E de Azambuja, D Dequanter… - Head & Neck …, 2006 - Wiley Online Library
Background. The aim of this article is to review recent developments in the biological
understanding of head and neck squamous cell carcinomas. Methods and Results. We …
understanding of head and neck squamous cell carcinomas. Methods and Results. We …
Prognostic significance of tumor angiogenesis, Ki 67, p53 oncoprotein, epidermal growth factor receptor and HER2 receptor protein expression in undifferentiated …
Background. This study prospectively examines the prognostic role of p53 oncoprotein
(p53), Ki67‐antigen (Ki67), tumor angiogenesis (MVD), epidermal growth factor receptor …
(p53), Ki67‐antigen (Ki67), tumor angiogenesis (MVD), epidermal growth factor receptor …
Hyaluronan and the interaction between CD44 and epidermal growth factor receptor in oncogenic signaling and chemotherapy resistance in head and neck cancer
SJ Wang, LYW Bourguignon - Archives of Otolaryngology–Head …, 2006 - jamanetwork.com
Objectives To investigate whether hyaluronan (HA) and CD44 (hereinafter HA-CD44)
promotes head and neck squamous cell carcinoma (HNSCC) chemotherapy resistance and …
promotes head and neck squamous cell carcinoma (HNSCC) chemotherapy resistance and …
HER2 as a therapeutic target in head and neck squamous cell carcinoma
NI Pollock, JR Grandis - Clinical Cancer Research, 2015 - AACR
The majority of patients with head and neck squamous cell carcinoma (HNSCC) present
with advanced-stage disease. The current standard of care is surgery followed by adjuvant …
with advanced-stage disease. The current standard of care is surgery followed by adjuvant …
Matrix hyaluronan-CD44 interaction activates MicroRNA and LncRNA signaling associated with chemoresistance, invasion, and tumor progression
LYW Bourguignon - Frontiers in oncology, 2019 - frontiersin.org
Tumor malignancies involve cancer cell growth, issue invasion, metastasis and often drug
resistance. A great deal of effort has been placed on searching for unique molecule (s) …
resistance. A great deal of effort has been placed on searching for unique molecule (s) …
Up-regulation of histone methyltransferase, DOT1L, by matrix hyaluronan promotes microRNA-10 expression leading to tumor cell invasion and chemoresistance in …
LYW Bourguignon, G Wong, M Shiina - Journal of Biological Chemistry, 2016 - ASBMB
Human head and neck squamous cell carcinoma is a solid tumor malignancy associated
with major morbidity and mortality. In this study, we determined that human head and neck …
with major morbidity and mortality. In this study, we determined that human head and neck …
The expression of p53, c-erbB-1 and c-erbB-2 molecules and their correlation with prognostic markers in patients with head and neck tumors
B Khademi, FM Shirazi, M Vasei, M Doroudchi… - Cancer letters, 2002 - Elsevier
Molecular prognostic and predictive factors have extensively been studied in different
cancers during the past decades, some of which were found to be useful in diagnosis, follow …
cancers during the past decades, some of which were found to be useful in diagnosis, follow …
Prognostic impact of HER‐2/neu expression on squamous head and neck carcinomas
A Cavalot, T Martone, N Roggero… - Head & Neck …, 2007 - Wiley Online Library
Abstract Background. HER‐2/neu gene amplification and protein overexpression have been
identified in various solid tumors, but its prognostic relevance in head and neck squamous …
identified in various solid tumors, but its prognostic relevance in head and neck squamous …
Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma
M Takikita, R Xie, JY Chung, H Cho, K Ylaya… - Journal of translational …, 2011 - Springer
Background Head and neck squamous cell carcinoma (HNSCC) still remains a lethal
malignancy benefiting from the identification of the new target for early detection and/or …
malignancy benefiting from the identification of the new target for early detection and/or …