Filopodia: molecular architecture and cellular functions
PK Mattila, P Lappalainen - Nature reviews Molecular cell biology, 2008 - nature.com
Filopodia are thin, actin-rich plasma-membrane protrusions that function as antennae for
cells to probe their environment. Consequently, filopodia have an important role in cell …
cells to probe their environment. Consequently, filopodia have an important role in cell …
The WASP–WAVE protein network: connecting the membrane to the cytoskeleton
T Takenawa, S Suetsugu - Nature reviews Molecular cell biology, 2007 - nature.com
Wiskott–Aldrich syndrome protein (WASP) and WASP-family verprolin-homologous protein
(WAVE) family proteins are scaffolds that link upstream signals to the activation of the …
(WAVE) family proteins are scaffolds that link upstream signals to the activation of the …
The role of the Rho GTPases in neuronal development
EE Govek, SE Newey, L Van Aelst - Genes & development, 2005 - genesdev.cshlp.org
Our brain serves as a center for cognitive function and neurons within the brain relay and
store information about our surroundings and experiences. Modulation of this complex …
store information about our surroundings and experiences. Modulation of this complex …
[HTML][HTML] Regulation of actin cytoskeleton dynamics in cells
SH Lee, R Dominguez - Molecules and cells, 2010 - Elsevier
The dynamic remolding of the actin cytoskeleton is a critical part of most cellular activities,
and malfunction of cytoskeletal proteins results in various human diseases. The transition …
and malfunction of cytoskeletal proteins results in various human diseases. The transition …
Filopodia and adhesion in cancer cell motility
Slender bundled actin containing plasma membrane protrusions, called filopodia, are
important for many essential cellular processes like cell adhesion, migration, angiogenesis …
important for many essential cellular processes like cell adhesion, migration, angiogenesis …
Mediation, modulation, and consequences of membrane-cytoskeleton interactions
GJ Doherty, HT McMahon - Annu. Rev. Biophys., 2008 - annualreviews.org
Elements of the cytoskeleton interact intimately and communicate bidirectionally with cellular
membranes. Such interactions are critical for a host of cellular processes. Here we focus on …
membranes. Such interactions are critical for a host of cellular processes. Here we focus on …
Variant-specific changes in RAC3 function disrupt corticogenesis in neurodevelopmental phenotypes
M Scala, M Nishikawa, H Ito, H Tabata, T Khan… - Brain, 2022 - academic.oup.com
Variants in RAC3, encoding a small GTPase RAC3 which is critical for the regulation of actin
cytoskeleton and intracellular signal transduction, are associated with a rare …
cytoskeleton and intracellular signal transduction, are associated with a rare …
[HTML][HTML] Missing-in-metastasis and IRSp53 deform PI (4, 5) P2-rich membranes by an inverse BAR domain–like mechanism
PK Mattila, A Pykäläinen, J Saarikangas… - The Journal of cell …, 2007 - ncbi.nlm.nih.gov
The actin cytoskeleton plays a fundamental role in various motile and morphogenetic
processes involving membrane dynamics. We show that actin-binding proteins MIM (missing …
processes involving membrane dynamics. We show that actin-binding proteins MIM (missing …
Sra‐1 and Nap1 link Rac to actin assembly driving lamellipodia formation
A Steffen, K Rottner, J Ehinger, M Innocenti… - The EMBO …, 2004 - embopress.org
The Rho‐GTPase Rac1 stimulates actin remodelling at the cell periphery by relaying signals
to Scar/WAVE proteins leading to activation of Arp2/3‐mediated actin polymerization …
to Scar/WAVE proteins leading to activation of Arp2/3‐mediated actin polymerization …
The making of filopodia
J Faix, K Rottner - Current opinion in cell biology, 2006 - Elsevier
Filopodia are rod-like cell surface projections filled with bundles of parallel actin filaments.
They are found on a variety of cell types and have been ascribed sensory or exploratory …
They are found on a variety of cell types and have been ascribed sensory or exploratory …