Filopodia are thin, actin-rich plasma-membrane protrusions that function as antennae for
cells to probe their environment. Consequently, filopodia have an important role in cell …

Wiskott–Aldrich syndrome protein (WASP) and WASP-family verprolin-homologous protein
(WAVE) family proteins are scaffolds that link upstream signals to the activation of the …

Our brain serves as a center for cognitive function and neurons within the brain relay and
store information about our surroundings and experiences. Modulation of this complex …

The dynamic remolding of the actin cytoskeleton is a critical part of most cellular activities,
and malfunction of cytoskeletal proteins results in various human diseases. The transition …

Slender bundled actin containing plasma membrane protrusions, called filopodia, are
important for many essential cellular processes like cell adhesion, migration, angiogenesis …

Elements of the cytoskeleton interact intimately and communicate bidirectionally with cellular
membranes. Such interactions are critical for a host of cellular processes. Here we focus on …

Variants in RAC3, encoding a small GTPase RAC3 which is critical for the regulation of actin
cytoskeleton and intracellular signal transduction, are associated with a rare …

The actin cytoskeleton plays a fundamental role in various motile and morphogenetic
processes involving membrane dynamics. We show that actin-binding proteins MIM (missing …

The Rho‐GTPase Rac1 stimulates actin remodelling at the cell periphery by relaying signals
to Scar/WAVE proteins leading to activation of Arp2/3‐mediated actin polymerization …

Filopodia are rod-like cell surface projections filled with bundles of parallel actin filaments.
They are found on a variety of cell types and have been ascribed sensory or exploratory …