Cancer stem cell metabolism: a potential target for cancer therapy

A Deshmukh, K Deshpande, F Arfuso, P Newsholme… - Molecular cancer, 2016 - Springer
Abstract Cancer Stem cells (CSCs) are a unipotent cell population present within the tumour
cell mass. CSCs are known to be highly chemo-resistant, and in recent years, they have …

A flow cytometric journey into cell cycle analysis

A Nair, SM Manohar - Bioanalysis, 2021 - Taylor & Francis
Cell cycle involves a series of changes that lead to cell growth and division. Cell cycle
analysis is crucial to understand cellular responses to changing environmental conditions …

Expression of multidrug resistance genes in normal and cancer stem cells

A Shervington, C Lu - Cancer investigation, 2008 - Taylor & Francis
CD133 (stem marker) and drug resistant gene (mdr1 and bcl-2) expression were detected in
human glioblastoma and normal brain tissues. Glioma tissues contained higher ratio of …

Secreted Frizzled-related protein 4 (sFRP4) chemo-sensitizes cancer stem cells derived from human breast, prostate, and ovary tumor cell lines

A Deshmukh, S Kumar, F Arfuso, P Newsholme… - Scientific reports, 2017 - nature.com
This study investigated molecular signals essential to sustain cancer stem cells (CSCs) and
assessed their activity in the presence of secreted frizzled-related protein 4 (sFRP4) alone or …

Role of epigenetic modulation in cancer stem cell fate

A Deshmukh, M Binju, F Arfuso, P Newsholme… - The international journal …, 2017 - Elsevier
A sub-population of the tumor micro-environment consists of cancer stem cells (CSCs),
which are responsible for the initiation and recurrence of cancer. Recently, epigenetic …

Synchronizing cell cycle of goat fibroblasts by serum starvation causes apoptosis

A Dalman, P Eftekhari‐Yazdi… - … in Domestic Animals, 2010 - Wiley Online Library
Contents Cell cycle stage and synchronization of donor cells are important factors
influencing the success of somatic cell nuclear transfer. This study examined whether serum …

Efficiency of gene transfection into donor cells for nuclear transfer of bovine embryos

SL Lee, SA Ock, JG Yoo, BM Kumar… - Molecular …, 2005 - Wiley Online Library
The production of transgenic (TG) animals by somatic cell nuclear transfer (SCNT) has
proven to be a more efficient method than other methods, such as gene injection or sperm …

Telomerase downregulation in cancer brain stem cell

A Shervington, C Lu, R Patel, L Shervington - Molecular and cellular …, 2009 - Springer
Cancer stem cells (CSCs) are a minute sub-population of self-renewing, immortal cells,
which can be responsible for chemoresistance observed in the treatment of cancer. CSCs …

Different culture conditions used for arresting the G0/G1 phase of the cell cycle in goldfish (Carassius auratus) caudal fin-derived fibroblasts

CH Choresca Jr, OJ Koo, HJ Oh, SG Hong… - Cell Biology …, 2009 - Elsevier
One of the most important factors determining the success of the development of cloned
embryos is the cell cycle stage of the donor cells. We investigated the effects of serum …

Survival of bovine fibroblasts and cumulus cells after vitrification

B Gajda, L Kątska-Książkiewicz, B Ryńska… - …, 2007 - ingentaconnect.com
The aim of the experiment was to investigate the effect of vitrification on viability and the cell
cycle of bovine cumulus cells and fibroblasts after culture with or without serum starvation. In …