Binge eating, overeating and food addiction: Approaches for examining food overconsumption in laboratory rodents

RM Brown, MH James - Progress in Neuro-Psychopharmacology and …, 2023 - Elsevier
Overeating ranges in severity from casual overindulgence to an overwhelming drive to
consume certain foods. At its most extreme, overeating can manifest as clinical diagnoses …

Obesity‐and diet‐induced plasticity in systems that control eating and energy balance

CR Ferrario, H Münzberg‐Gruening, L Rinaman… - …, 2024 - Wiley Online Library
Abstract In April 2023, the National Institute of Diabetes and Digestive and Kidney Diseases
(NIDDK), in partnership with the National Institute of Child Health and Human Development …

Linking drug and food addiction: an overview of the shared neural circuits and behavioral phenotype

A Passeri, D Municchi, G Cavalieri… - Frontiers in Behavioral …, 2023 - frontiersin.org
Despite a lack of agreement on its definition and inclusion as a specific diagnosable
disturbance, the food addiction construct is supported by several neurobiological and …

A molecularly defined orbitofrontal cortical neuron population controls compulsive-like behavior, but not inflexible choice or habit

ST Yount, S Wang, AT Allen, LP Shapiro… - Progress in …, 2024 - Elsevier
Habits are familiar behaviors triggered by cues, not outcome predictability, and are
insensitive to changes in the environment. They are adaptive under many circumstances but …

Short-and long-term high-fat diet exposure differentially alters phasic and tonic GABAergic signaling onto lateral orbitofrontal pyramidal neurons

LT Seabrook, CS Peterson, D Noble… - Journal of …, 2023 - Soc Neuroscience
The chronic consumption of caloric dense high-fat foods is a major contributor to increased
body weight, obesity, and other chronic health conditions. The orbitofrontal cortex (OFC) is …

Disinhibition Is an Essential Network Motif Coordinated by GABA Levels and GABA B Receptors

N Villalobos - International Journal of Molecular Sciences, 2024 - mdpi.com
Network dynamics are crucial for action and sensation. Changes in synaptic physiology lead
to the reorganization of local microcircuits. Consequently, the functional state of the network …

In silico and functional analysis identifies key gene networks and novel gene candidates in obesity‐linked human visceral fat

L Wang, PV Seshachalam, R Chua, H Zhou, S Lei… - …, 2024 - Wiley Online Library
Objective Visceral adiposity is associated with increased proinflammatory activity, insulin
resistance, diabetes risk, and mortality rate. Numerous individual genes have been …

[HTML][HTML] Computational mechanisms underpinning greater exploratory behaviour in excess weight relative to healthy weight adolescents

J Halim, AH Robinson, JF Navas, C Martin-Perez… - Appetite, 2023 - Elsevier
Obesity in adolescence is associated with cognitive changes that lead to difficulties in
shifting unhealthy habits in favour of alternative healthy behaviours, similar to addictive …

[HTML][HTML] Consuming Fat and Sugar (At The Same Time) Promotes Overeating, Study Finds

V Hedrih, CNP Staff - CNP Articles in Nutritional …, 2024 - nutritional-psychology.org
Consuming Fat and Sugar Promotes Overeating, Study Finds Nutrition psychology Search
Search Nutritional Psychology Home What is Nutritional Psychology? About CNP Our Mission …

Elevated body mass index in youth is associated with dysregulated surrogate markers of neural inhibition & excitation, and internetwork functional dysconnectivity

AC Reichelt, E Daskalakis, J Cohen, KG Solar… - bioRxiv, 2024 - biorxiv.org
The developing child and adolescent brain is thought to have an increased vulnerability to
the negative impact of obesity and excessive consumption of hyperpalatable and energy …