Reactive oxygen species continuously assault the structure of DNA resulting in oxidation
and fragmentation of the nucleobases. Both oxidative DNA damage itself and its repair …

Base excision repair (BER) proteins act upon a significantly broad spectrum of DNA lesions
that result from endogenous and exogenous sources. Multiple sub-pathways of BER (short …

We present an updated and integrated version of our widely used protein–protein docking
and binding affinity benchmarks. The benchmarks consist of non-redundant, high-quality …

Scaffold proteins play a central role in DNA repair by recruiting and organizing sets of
enzymes required to perform multi-step repair processes. X-ray cross complementing group …

Abstract Poly (ADP-ribose) polymerase 1 (PARP1, also known as ADPRT1) is a
multifunctional human ADP-ribosyltransferase. It plays a role in multiple DNA repair …

Upon the occurrence of DNA double strand breaks (DSB), the proximal histone variant H2A.
X is phosphorylated as γ-H2A. X, a critical signal for consequent DSB signaling and repair …

Introduction 3. Conventional and atypical sequence motifs 3.1. Canonical peptide motifs
recognized by the SH3 domains 3.2. Atypical SH3-binding motifs 3.3. The RxxK motif 4 …

BRCA1 C-terminal (BRCT) domains are integral signaling modules in the DNA damage
response (DDR). Aside from their established roles as phospho-peptide binding modules …

Abstract Base Excision Repair (BER) efficiently corrects the most common types of DNA
damage in mammalian cells. Step-by-step coordination of BER is facilitated by multiple …

ABSTRACT ADP-ribose is a versatile modification that plays a critical role in diverse cellular
processes. The addition of this modification is catalyzed by ADP-ribosyltransferases, among …