Abstract Purpose of the Review Bisphosphonates have well-established effects on
suppressing bone resorption and slowing bone loss, yet the effects on bone mechanical …

Preclinical studies play an indispensable role in exploring the biological regulation of the
musculoskeletal system. They are required in all drug development pipelines where both …

Current interventions to reduce skeletal fragility are insufficient at enhancing both the
quantity and quality of bone when attempting to improve overall mechanical integrity …

Introduction Bisphosphonate (BF) therapy is strongly related to the occurrence of medication-
related osteonecrosis of the jaw (ONJ). However, no previous study has evaluated if there …

The small GTP-binding protein Rad (RRAD, Ras associated with diabetes) is the founding
member of the RGK (Rad, Rem, Rem2, and Gem/Kir) family that regulates cardiac voltage …

Objective: To investigate the efficacy of ibandronate sodium and zoledronate sodium in the
treatment of senile osteoporosis and their impact on quality of life, and to analyze the cost …

Bisphosphonates represent the gold-standard pharmaceutical agent for reducing fracture
risk. Long-term treatment with bisphosphonates can result in tissue brittleness which in rare …

As a daily physiological mechanism in bone, microdamage accumulation dissipates energy
and helps to prevent fractures. However, excessive damage accumulation might bring …

Purpose Patients with chronic kidney disease (CKD) have high risk of fracture in part due to
cortical bone deterioration. The goal of this study was to assess the impact of two different …

The term bone quality refers to factors that define bone mechanical strength and hence its
fracture risk, either inclusive or exclusive of the quantity of mineralized tissue present. These …