Polycystic ovary syndrome (PCOS) is among the most common disorders in women of
reproductive age, affecting up to 15% worldwide, depending on the diagnostic criteria …

Early‐onset Alzheimer's disease (EOAD) is generally known as a dominant disease due to
highly penetrant pathogenic mutations in the amyloid precursor protein, presenilin 1 and 2 …

We present a consensus atlas of the human brain transcriptome in Alzheimer's disease
(AD), based on meta-analysis of differential gene expression in 2,114 postmortem samples …

Evidence suggests interplay among the three major risk factors for Alzheimer's disease (AD):
age, APOE genotype, and sex. Here, we present comprehensive datasets and analyses of …

Alzheimer's disease (AD) is a chronic neurodegenerative disease characterised by cognitive
impairment, behavioural alteration, and functional decline. Over 130 AD-associated …

The incidence of Alzheimer's Disease in females is almost double that of males. To search
for sex-specific gene associations, we build a machine learning approach focused on …

Neurogenesis, crucial for brain resilience, is reduced in Alzheimer's disease (AD) that
induces astroglial reactivity at the expense of the pro-neurogenic potential, and restoring …

Recently, large-scale human genetics studies identified a rare coding variant in the ABI3
gene that is associated with an increased risk of Alzheimer's disease (AD). However …

The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously
associated with a reduced Alzheimer's disease risk (AD). The role of PLCG2 in immune …

Abstract Phosphoinositide-specific phospholipase Cs (PLCs) are expressed in all
mammalian cells and play critical roles in signal transduction. To obtain a comprehensive …