Ultrasound microbubble contrast agents: fundamentals and application to gene and drug delivery

K Ferrara, R Pollard, M Borden - Annu. Rev. Biomed. Eng., 2007 - annualreviews.org
This review offers a critical analysis of the state of the art of medical microbubbles and their
application in therapeutic delivery and monitoring. When driven by an ultrasonic pulse …

Quantitative contrast-enhanced ultrasound imaging: a review of sources of variability

MX Tang, H Mulvana, T Gauthier, AKP Lim… - Interface …, 2011 - royalsocietypublishing.org
Ultrasound provides a valuable tool for medical diagnosis offering real-time imaging with
excellent spatial resolution and low cost. The advent of microbubble contrast agents has …

In situ conversion of porphyrin microbubbles to nanoparticles for multimodality imaging

E Huynh, BYC Leung, BL Helfield, M Shakiba… - Nature …, 2015 - nature.com
Converting nanoparticles or monomeric compounds into larger supramolecular structures by
endogenous, or external, stimuli is increasingly popular because these materials are useful …

Gain an advantage from both sides: Smart size-shrinkable drug delivery nanosystems for high accumulation and deep penetration

S Bai, Y Zhang, D Li, X Shi, G Lin, G Liu - Nano Today, 2021 - Elsevier
The first generation of nanomedicine exhibits superior performance in the clinical treatment
of various cancers compared to free conventional anticancer therapeutics. However, poor …

Response of contrast agents to ultrasound

V Sboros - Advanced drug delivery reviews, 2008 - Elsevier
Microbubbles are used as ultrasonic contrast agents that enhance the ultrasound signals of
the vascular bed. The recent development of site-targeted microbubbles opened up the …

Growth and dissolution of an encapsulated contrast microbubble: effects of encapsulation permeability

K Sarkar, A Katiyar, P Jain - Ultrasound in medicine & biology, 2009 - Elsevier
Gas diffusion from an encapsulated microbubble is modeled using an explicit linear relation
for gas permeation through the encapsulation. Both the cases of single gas (air) and multiple …

Effects of encapsulation elasticity on the stability of an encapsulated microbubble

A Katiyar, K Sarkar, P Jain - Journal of Colloid and Interface Science, 2009 - Elsevier
A model for gas transport from an encapsulated microbubble into the surrounding medium is
developed and investigated incorporating the effects of encapsulation elasticity …

Ultrasound-mediated destruction of contrast microbubbles used for medical imaging and drug delivery

D Chatterjee, P Jain, K Sarkar - Physics of Fluids, 2005 - pubs.aip.org
Micron-size bubbles encapsulated by a stabilizing layer of surface-active materials are used
in medical ultrasound imaging and drug delivery. Their destruction stimulated by ultrasound …

The behaviour of individual contrast agent microbubbles

V Sboros, CM Moran, SD Pye, WN McDicken - Ultrasound in medicine & …, 2003 - Elsevier
In recent years, our knowledge of the behaviour of ultrasonic microbubble contrast agents
has improved substantially through in vitro experiments. However, there has been a …

Destruction thresholds of echogenic liposomes with clinical diagnostic ultrasound

DAB Smith, TM Porter, J Martinez, S Huang… - Ultrasound in medicine …, 2007 - Elsevier
Echogenic liposomes (ELIP) are submicron-sized phospholipid vesicles that contain both
gas and fluid. With antibody conjugation and drug incorporation, these liposomes can be …