Ion activation methods for peptides and proteins

LA Macias, IC Santos, JS Brodbelt - Analytical chemistry, 2019 - ACS Publications
Mass spectrometry is well-established as one of the primary methods used to characterize
peptides and proteins. New advances in instrumentation and innovative analytical workflows …

Two-dimensional mass spectrometry: new perspectives for tandem mass spectrometry

MA van Agthoven, YPY Lam, PB O'Connor… - European Biophysics …, 2019 - Springer
Fourier transform ion cyclotron resonance mass analysers (FT-ICR MS) can offer the highest
resolutions and mass accuracies in mass spectrometry. Mass spectra acquired in an FT-ICR …

Two-Dimensional Mass Spectrometry Analysis of IgG1 Antibodies

J Paris, TE Morgan, BP Marzullo… - Journal of the …, 2021 - ACS Publications
Two-dimensional mass spectrometry (2DMS) is a new, and theoretically ideal, data-
independent analysis tool, which allows the characterization of a complex mixture and was …

Characterization across a dispersity: polymer mass spectrometry in the second dimension

TE Morgan, CA Wootton, B Marzullo… - Journal of the …, 2021 - ACS Publications
Due to the natural dispersity that is present in synthetic polymers, an added complexity is
always present in the analysis of polymeric species. Tandem mass spectrometry analysis …

Differentiation of leucine and isoleucine residues in peptides using charge transfer dissociation mass spectrometry (CTD‐MS)

HM Edwards, HT Wu, RR Julian… - … in Mass Spectrometry, 2022 - Wiley Online Library
Rationale The function of a protein or the binding affinity of an antibody can be substantially
altered by the replacement of leucine (Leu) with isoleucine (Ile), and vice versa, so the ability …

Combining ultraviolet photodissociation and two-dimensional mass spectrometry: a contemporary approach for characterizing singly charged agrochemicals

BP Marzullo, TE Morgan, A Theisen, A Haris… - Analytical …, 2021 - ACS Publications
Ultraviolet photodissociation (UVPD) has been shown to produce extensive structurally
informative data for a variety of chemically diverse compounds. Herein, we demonstrate the …

Ultra-Accurate Correlation between Precursor and Fragment Ions in Two-Dimensional Mass Spectrometry: Acetylated vs Trimethylated Histone Peptides

M Palasser, SV Heel, MA Delsuc… - Journal of the …, 2023 - ACS Publications
Two-dimensional mass spectrometry (2D MS) is a method for tandem mass spectrometry in
which precursor and fragment ions are correlated by manipulating ion radii rather than by …

Narrowband Modulation Two-Dimensional Mass Spectrometry and Label-Free Relative Quantification of Histone Peptides

M Halper, MA Delsuc, K Breuker… - Analytical …, 2020 - ACS Publications
Two-dimensional mass spectrometry (2D MS) on a Fourier transform ion cyclotron
resonance (FT-ICR) mass analyzer allows for tandem mass spectrometry without requiring …

Advantages of two-dimensional electron-induced dissociation and infrared multiphoton dissociation mass spectrometry for the analysis of agrochemicals

BP Marzullo, TE Morgan, CA Wootton… - Analytical …, 2020 - ACS Publications
Analysis of agrochemicals in an environmental matrix is challenging because these samples
contain multiple agrochemicals, their metabolites, degradation products, and endogenous …

Two-dimensional tandem mass spectrometry in a single scan on a linear quadrupole ion trap

DT Snyder, LJ Szalwinski, Z St. John… - Analytical …, 2019 - ACS Publications
A two-dimensional tandem mass spectrometry (2D MS/MS) scan has been developed for the
linear quadrupole ion trap. Precursor ions are mass-selectively excited using a nonlinear ac …