Pulmonary delivery nanomedicines towards circumventing physiological barriers: Strategies and characterization approaches

W Wang, Z Huang, Y Huang, X Zhang, J Huang… - Advanced Drug Delivery …, 2022 - Elsevier
Pulmonary delivery of nanomedicines is very promising in lung local disease treatments
whereas several physiological barriers limit its application via the interaction with inhaled …

The Lord of the Lungs: The essential role of pulmonary surfactant upon inhalation of nanoparticles

C Garcia-Mouton, A Hidalgo, A Cruz… - European Journal of …, 2019 - Elsevier
The rapid development of nanotechnology is opening a huge world of promising
possibilities in healthcare, but this is also increasing the necessity to study the potential risk …

[HTML][HTML] Application of nanotechnology in drug delivery systems for respiratory diseases

MX Luo, S Hua, QY Shang - Molecular Medicine …, 2021 - spandidos-publications.com
Respiratory disease is a common disease with a high incidence worldwide, which is a
serious threat to human health, and is considered a societal and economic burden. The …

Pivotal roles of metal oxides in the formation of environmentally persistent free radicals

L Yang, G Liu, M Zheng, R Jin, Y Zhao… - … Science & Technology, 2017 - ACS Publications
Environmentally persistent free radicals (EPFRs) are emerging pollutants that can adversely
affect human health. Although the pivotal roles of metal oxides in EPFR formation have been …

Microplastics and nanoplastics impair the biophysical function of pulmonary surfactant by forming heteroaggregates at the alveolar–capillary interface

X Xu, RA Goros, Z Dong, X Meng, G Li… - Environmental …, 2023 - ACS Publications
Microplastics (MPs) are ubiquitous environmental pollutants produced through the
degradation of plastic products. Nanoplastics (NPs), commonly coexisting with MPs in the …

[HTML][HTML] Engineering of pulmonary surfactant corona on inhaled nanoparticles to operate in the lung system

M Falahati, A Hasan, HA Zeinabad, V Serpooshan… - Nano Today, 2023 - Elsevier
Exposure of inhaled nanoparticles (NPs) to the deep lung tissue results in the adsorption of
pulmonary surfactant (PSf) on the surface of NPs and the formation of a biomolecular …

The emergence of nanoporous materials in lung cancer therapy

D Radhakrishnan, S Mohanan, G Choi… - … and technology of …, 2022 - Taylor & Francis
Lung cancer is one of the most common cancers, affecting more than 2.1 million people
across the globe every year. A very high occurrence and mortality rate of lung cancer have …

[HTML][HTML] Polymeric Nanoparticles for Inhaled Vaccines

NK Al-Nemrawi, RS Darweesh, LA Al-Shriem… - Polymers, 2022 - mdpi.com
Many recent studies focus on the pulmonary delivery of vaccines as it is needle-free, safe,
and effective. Inhaled vaccines enhance systemic and mucosal immunization but still faces …

Nano-therapeutics for the lung: state-of-the-art and future perspectives

R Iyer, C CW Hsia, KT Nguyen - Current pharmaceutical …, 2015 - ingentaconnect.com
Inhalation of aerosolized compounds is a popular, non-invasive route for the targeted
delivery of therapeutic molecules to the lung. Various types of nanoparticles have been used …

The effects of physicochemical properties of nanomaterials on their cellular uptake in vitro and in vivo

Y Liu, B Workalemahu, X Jiang - Small, 2017 - Wiley Online Library
Understanding the cellular uptake of nanomaterials (NMs) is a fundamental and critical
issue for uncovering biomedical effects of NMs and facilitating their practical applications in …