Dysregulated haemostasis in thrombo-inflammatory disease

PA Klavina, G Leon, AM Curtis, RJS Preston - Clinical Science, 2022 - portlandpress.com
Inflammatory disease is often associated with an increased incidence of venous
thromboembolism in affected patients, although in most instances, the mechanistic basis for …

The protein C pathways

G Leon, AM Rehill, RJS Preston - Current Opinion in Hematology, 2022 - journals.lww.com
The protein C pathways : Current Opinion in Hematology The protein C pathways : Current
Opinion in Hematology Log in or Register Subscribe to journalSubscribe Get new issue alertsGet …

[HTML][HTML] Activated protein C protects against murine contact dermatitis by suppressing protease-activated receptor 2

M Xue, H Lin, R Zhao, C Fryer, L March… - International Journal of …, 2022 - mdpi.com
Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with excessive
inflammation and defective skin barrier function. Activated protein C (APC) is a natural …

Endothelial cell protein C receptor regulates neutrophil extracellular trap–mediated rheumatoid arthritis disease progression

X Liu, Y Huo, J Zhao, G Wang, H Liu, F Yin… - International …, 2022 - Elsevier
Endothelial cell protein C receptor (EPCR) is a 46 kDa transmembrane protein receptor,
expressed in most immune cells (T cells, monocytes, dendritic cells, polymorphonuclear …

Thrombin generation and activity in multiple sclerosis

KR Jordan, I Parra-Izquierdo, A Gruber, JJ Shatzel… - Metabolic brain …, 2021 - Springer
The coagulation cascade and immune system are intricately linked, highly regulated and
respond cooperatively in response to injury and infection. Increasingly, evidence of hyper …

Imbalanced coagulation in the airway of type-2 high asthma with comorbid obesity

JT Womble, VL McQuade, MD Ihrie… - Journal of asthma and …, 2021 - Taylor & Francis
Asthma is a common, chronic airway inflammatory disease marked by airway
hyperresponsiveness, inflammation, and remodeling. Asthma incidence has increased …

The immunoregulatory activities of activated protein C in inflammatory disease

CJ McDonnell, EE Soule, PT Walsh… - … in Thrombosis and …, 2018 - thieme-connect.com
Tissue injury prompts the initiation of host defense responses to limit blood loss, restrict
pathogen entry, and promote repair. Biochemical and cellular pathways that lead to blood …

APC-EPCR-PAR1 通路在类风湿关节炎中的研究进展.

刘轩绮, 刘汇洋, 赵京洋, 尹芳蕊, 白力… - Tianjin Medical …, 2022 - search.ebscohost.com
类风湿关节炎(RA) 是一种慢性, 系统性自身免疫性疾病. 活化蛋白C (APC) 是由其前体蛋白C
(PC) 转化而来的一种天然抗凝血剂, 在凝血调控中起着关键的作用. APC 可与内皮蛋白C …

[HTML][HTML] Natural coagulation inhibitors in liver diseases

AK Al-Ghumlas - Journal of Applied Hematology, 2016 - journals.lww.com
The hemostatic derangements accompanying liver disease are complex and affect all
aspects of hemostasis. Depressed levels of the major natural anticoagulants (NAs) …

Dendritic Cells and Immunomodulation: Role in Health and Disease

SK Thokchom, K Gulati, T Thakur… - Current Immunology …, 2017 - benthamdirect.com
Background: In this article, we aimed to discuss the current status of Dendritic cells (DCs),
their subtypes, characteristics and role in immune responses and highlighted their …