Sweetening the hallmarks of cancer: Galectins as multifunctional mediators of tumor progression

MR Girotti, M Salatino, T Dalotto-Moreno… - Journal of Experimental …, 2019 - rupress.org
Hanahan and Weinberg have proposed 10 organizing principles that enable growth and
metastatic dissemination of cancer cells. These distinctive and complementary capabilities …

Galectin-9 as a biomarker of disease severity

P Moar, R Tandon - Cellular immunology, 2021 - Elsevier
Abstract Galectin-9 (Gal-9) is a β-galactoside binding lectin known for its immunomodulatory
role in various microbial infections. Gal-9 is expressed in all organ systems and localized in …

Galectins and immune responses—just how do they do those things they do?

S Thiemann, LG Baum - Annual review of immunology, 2016 - annualreviews.org
Galectins are a family of mammalian carbohydrate-binding proteins expressed by many cell
types. Galectins can function intracellularly and can also be secreted to bind to cell surface …

The role of galectins as modulators of metabolism and inflammation

MF Brinchmann, DM Patel… - Mediators of …, 2018 - Wiley Online Library
Galectins are β‐galcotosid‐binding lectins. The function of galectins varies with their tissue‐
specific and subcellular location, and their binding to carbohydrates makes them key players …

The molecular brakes of adipose tissue lipolysis

Y Li, Z Li, DA Ngandiri, M Llerins Perez, A Wolf… - Frontiers in …, 2022 - frontiersin.org
Adaptation to changes in energy availability is pivotal for the survival of animals. Adipose
tissue, the body's largest reservoir of energy and a major source of metabolic fuel, exerts a …

The role of galectins in immunity and infection

FT Liu, SR Stowell - Nature Reviews Immunology, 2023 - nature.com
The galectin family consists of carbohydrate (glycan) binding proteins that are expressed by
a wide variety of cells and bind to galactose-containing glycans. Galectins can be located in …

Evolving mechanistic insights into galectin functions

CM Arthur, MD Baruffi, RD Cummings… - Galectins: Methods and …, 2015 - Springer
Galectins are an evolutionarily ancient family of glycan-binding proteins (GBPs) and are
found in all animals. Although they were discovered over 30 years ago, ideas about their …

Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects

S Chatree, C Sitticharoon, P Maikaew… - Experimental …, 2021 - journals.sagepub.com
Obesity is one of major risk factors increasing chronic diseases including type II diabetes,
cardiovascular diseases, and hypertension. The effects of epigallocatechin gallate (EGCG) …

Galectins: an ancient family of carbohydrate binding proteins with modern functions

H Verkerke, M Dias-Baruffi, RD Cummings… - Galectins: Methods and …, 2022 - Springer
Galectins are a large family of carbohydrate binding proteins with members in nearly every
lineage of multicellular life. Through tandem and en-mass genome duplications, over 15 …

Intracellular galectins in cancer cells: potential new targets for therapy

MC Vladoiu, M Labrie… - … journal of oncology, 2014 - spandidos-publications.com
Dysregulation of galectin expression is frequently observed in cancer tissues. Such an
abnormal expression pattern often correlates with aggressiveness and relapse in many …