Background The early life environment experienced by an individual in utero and during the
neonatal period is a major factor in shaping later life disease risk-including susceptibility to …

Over the past two decades, evidence has accumulated that neurogenesis can occur in both
the juvenile and adult mammalian hypothalamus. Levels of hypothalamic neurogenesis can …

Abstract Background Interleukin-6 (IL6) produced in the context of exercise acts in the
hypothalamus reducing obesity-associated inflammation and restoring the control of food …

Decreased estrogens during menopause are associated with increased risk of anxiety,
depression, type 2 diabetes and obesity. Similarly, depleting estrogens in rodents by …

Estrogens protect against diet-induced obesity in women and female rodents. For example,
a lack of estrogens in postmenopausal women is associated with an increased risk of weight …

The generation of new neurons in the adult brain is a currently accepted phenomenon. Over
the past few decades, the subventricular zone and the hippocampal dentate gyrus have …

The search for new strategies and drugs to abate the current obesity epidemic has led to the
intensification of research aimed at understanding the neuroendocrine control of appetite …

Social recognition is the sensitive domains of complex behavior critical for identification,
interpretation and storage of socially meaningful information. Social recognition develops …

A decrease in ovarian estrogens in postmenopausal women increases the risk of weight
gain, cardiovascular disease, type 2 diabetes, and chronic inflammation. While it is known …

Estrogens protect against weight gain and metabolic disruption in women and female
rodents. Aberrations in the gut microbiota composition are linked to obesity and metabolic …