The α7-type nicotinic acetylcholine receptor is one of the most unique and interesting of all
the members of the cys-loop superfamily of ligand-gated ion channels. Since it was first …

The nicotinic acetylcholine receptor (nAChR) represents the prototype of ligand-gated ion
channels. It is vital for neuromuscular transmission and an important regulator of …

Venom peptide toxins such as conotoxins play a critical role in the characterization of
nicotinic acetylcholine receptor (nAChR) structure and function and have potential as …

The α3β2 and α3β4 nicotinic acetylcholine receptors (nAChRs) are widely expressed in the
central and peripheral nervous systems, playing critical roles in various physiological …

Marine cone snails are carnivorous gastropods that use peptide toxins called conopeptides
both as a defense mechanism and as a means to immobilize and kill their prey. These …

Understanding the determinants of α-conotoxin (α-CTX) selectivity for different nicotinic
acetylcholine receptor (nAChR) subtypes is a prerequisite for the design of tool compounds …

Nicotinic acetylcholine receptors (nAChR) are therapeutic targets for a range of human
diseases. α-Conotoxins are naturally occurring peptide antagonists of nAChRs that have …

Nicotinic acetylcholine receptors (nAChRs) are found throughout the mammalian body and
have been studied extensively because of their implication in a myriad of diseases. α …

Nicotinic acetylcholine receptor (nAChR) subtypes are key drug targets, but it is challenging
to pharmacologically differentiate between them because of their highly similar sequence …

As ligand-gated ion channels, nicotinic acetylcholine receptors (nAChRs) are widely
distributed in the central and peripheral nervous systems and are associated with the …