This review integrates from the single muscle fibre to exercising human the current
understanding of the role of skeletal muscle for whole-body potassium (K+) regulation, and …

This review discusses selective and fast transport of ionic species (ions and their associates)
through systems as diverse as ion-conducting transmembrane proteins and ion exchange …

C-type inactivation is of great physiological importance in voltage-activated K+ channels
(Kv), but its structural basis remains unresolved. Knowledge about C-type inactivation has …

Ions transiting biomembranes might pass readily from water through ion-specific membrane
proteins if these protein channels provide environments similar to the aqueous solution …

The K+ channel selectivity filter (SF) is defined by TxGYG amino acid sequences that
generate four identical K+ binding sites (S1-S4). Only two sites (S3, S4) are present in the …

The ability to reversibly and non-invasively modulate region-specific brain activity in vivo
suggests Low Intensity Focused Ultrasound (LIFU) as potential therapeutics for neurological …

The hydration structure of Ba2+ ion is important for understanding blocking mechanisms in
potassium ion channels. Here, we combine statistical mechanical theory, ab initio molecular …

Ion hydration structure and free energy establish criteria for understanding selective ion
binding in potassium (K+) ion channels and may be significant to understanding blocking …

The T WIK-re lated s pinal cord K+ channel (TRESK, K2P18. 1) is a K2P channel
contributing to the maintenance of membrane potentials in various cells. Recently …

Abstract Barium (Ba 2+) is a classic permeant blocker of potassium (K+) channels. The
“external lock-in effect” in barium block experiments, whereby the binding of external K+ …