Glyphosate-induced mitochondrial reactive oxygen species overproduction activates parkin-dependent mitophagy to inhibit testosterone synthesis in mouse leydig …

L Lu, JB Liu, JQ Wang, CY Lian, ZY Wang… - Environmental Pollution, 2022 - Elsevier
Glyphosate (GLY), one of the most extensively used herbicides in the world, has been
shown to inhibit testosterone synthesis in male animals. Mitochondria are crucial organelles …

Microglia-derived exosomes modulate myelin regeneration via miR-615-5p/MYRF axis

XY Ji, YX Guo, LB Wang, WC Wu, JQ Wang… - Journal of …, 2024 - Springer
Demyelination and failure of remyelination in the central nervous system (CNS) characterize
a number of neurological disorders. Spontaneous remyelination in demyelinating diseases …

[HTML][HTML] High seminal BPA in IVF patients correlates with lower sperm count and up-regulated miR-21 and miR-130a

OS Davis, OLM Scandlan, R Sabry… - Reproductive …, 2024 - Elsevier
Bisphenol A (BPA) is a widespread industrial chemical, used as the key monomer of
polycarbonate plastics and epoxy resins. BPA has been detected in human seminal fluid …

MicroRNA-21 (miR-21) in breast cancer: From apoptosis dysregulation to therapeutic opportunities

RU Syed, H Banu, AD Alshammari… - … -Research and Practice, 2024 - Elsevier
Breast cancer, a pervasive and complex disease, continues to pose significant challenges in
the field of oncology. Its heterogeneous nature and diverse molecular profiles necessitate a …

Comprehensive transcriptional analysis of pig facial skin development

Y Li, R Shi, R Yuan, Y Jiang - PeerJ, 2023 - peerj.com
Background Skin development is a complex process that is influenced by many factors. Pig
skin is used as an ideal material for xenografts because it is more anatomically and …

PRP8-induced CircMaml2 facilitates the healing of the intestinal mucosa via recruiting PTBP1 and regulating Sec62

Y Deng, X Xu, F Meng, J Lou, Y Liao, Q Li, M Zhuang… - Cells, 2022 - mdpi.com
Background: Multiple organ dysfunction syndrome (MODS) occurs in the gastrointestinal
tract and injured intestinal mucosa is the anatomical basis for various diseases. The …

Chlorpyrifos induces male infertility in pigs through ROS and PI3K-AKT pathway

X Zhang, M Li, W Li, L Yue, T Zhang, Q Tang, N Zhang… - Iscience, 2023 - cell.com
Chlorpyrifos (CPF) has been shown to have male reproductive toxicity in mice and rat.
However, the association of CPF and male reproduction in pigs remains unknown …

Investigation of LncRNA PVT1 and MiR-21-5p Expression as Promising Novel Biomarkers for Autism Spectrum Disorder

M Jiang, G Chen - Journal of Molecular Neuroscience, 2023 - Springer
The characteristics of ncRNA in children with autism spectrum disorder (ASD) were
observed to disclose a theoretical basis for further research on molecular markers for early …

Ssc-miR-429 expression proliles and functions on inducing Leydig cells apoptosis

Q Tang, Y Zhang, L Yue, H Ren, C Pan - Theriogenology, 2024 - Elsevier
Leydig cells (LCs) play an indispensable role in testosterone synthesis, and their
dysfunction can result in male reproductive disorders. Previous transcriptome sequencing …

miR‐429 inhibits palmitic acid‐induced apoptosis of porcine subcutaneous preadipocytes by targeting Sox5

Y Hua, H Cao, Y Peng, J Liu, X Li… - Animal Research and …, 2024 - Wiley Online Library
MicroRNAs (miRNAs) can regulate several physiological processes of cells after
transcription, such as cell proliferation, differentiation, and apoptosis. In this study, we found …