Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions

A Jarrahi, M Braun, M Ahluwalia, RV Gupta, M Wilson… - Biomedicines, 2020 - mdpi.com
Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …

CB2 receptor in microglia: the guardian of self-control

JA Komorowska-Müller, AC Schmöle - International journal of molecular …, 2020 - mdpi.com
Microglia are key to maintaining the homeostasis of the brain. These immune cells of the
brain can be our biggest ally in fighting infections, but can worsen pathology or hinder …

Cannabinoid receptors: An update on cell signaling, pathophysiological roles and therapeutic opportunities in neurological, cardiovascular, and inflammatory …

D Haspula, MA Clark - International journal of molecular sciences, 2020 - mdpi.com
The identification of the human cannabinoid receptors and their roles in health and disease,
has been one of the most significant biochemical and pharmacological advancements to …

[HTML][HTML] CB2R activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological …

J Li, H Wang, D Liu, X Li, L He, J Pan, Q Shen… - Brain, Behavior, and …, 2023 - Elsevier
Background Chronic alcohol exposure (CAE) during late adolescence increases the risk of
anxiety development. Alcohol-induced prefrontal cortex (PFC) microglial activation …

Endocannabinoid modulation of microglial phenotypes in neuropathology

M Tanaka, S Sackett, Y Zhang - Frontiers in Neurology, 2020 - frontiersin.org
Microglia, the resident immune cells of the central nervous system, mediate brain
homeostasis by controlling neuronal proliferation/differentiation and synaptic activity. In …

Neurological consequences of COVID-19: what have we learned and where do we go from here?

A Jarrahi, M Ahluwalia, H Khodadadi… - Journal of …, 2020 - Springer
Abstract The coronavirus disease-19 (COVID-19) pandemic is an unprecedented worldwide
health crisis. COVID-19 is caused by SARS-CoV-2, a highly infectious pathogen that is …

Endocannabinoid system as a promising therapeutic target in inflammatory bowel disease–a systematic review

S Hryhorowicz, M Kaczmarek-Ryś, A Zielińska… - Frontiers in …, 2021 - frontiersin.org
Inflammatory bowel disease (IBD) is a general term used to describe a group of chronic
inflammatory conditions of the gastrointestinal tract of unknown etiology, including two …

Cannabinoid receptor type 2: a possible target in SARS-CoV-2 (CoV-19) infection?

F Rossi, C Tortora, M Argenziano, A Di Paola… - International Journal of …, 2020 - mdpi.com
In late December 2019, a novel coronavirus (SARS-CoV-2 or CoV-19) appeared in Wuhan,
China, causing a global pandemic. SARS-CoV-2 causes mild to severe respiratory tract …

CB2 receptor in the CNS: From immune and neuronal modulation to behavior

W Grabon, S Rheims, J Smith, J Bodennec… - Neuroscience & …, 2023 - Elsevier
Despite low levels of cannabinoid receptor type 2 (CB2R) expression in the central nervous
system in human and rodents, a growing body of evidence shows CB2R involvement in …

The treatment of cognitive, behavioural and motor impairments from brain injury and neurodegenerative diseases through cannabinoid system modulation—evidence …

D Calina, AM Buga, M Mitroi, A Buha… - Journal of Clinical …, 2020 - mdpi.com
Neurological disorders such as neurodegenerative diseases or traumatic brain injury are
associated with cognitive, motor and behavioural changes that influence the quality of life of …