The loss of vital cells within healthy tissues contributes to the development, progression and
treatment outcomes of many human disorders, including neurological and infectious …

Apoptosis is a cell suicide process that is essential for development, tissue homeostasis and
human health. Impaired apoptosis is associated with a variety of human diseases, including …

Understanding the molecular events controlling melanoma progression is of paramount
importance for the development of alternative treatment options for this devastating disease …

Abstract Serine Threonine Tyrosine Kinase 1 (STYK1) presents oncogenic properties in
many studies, and emerging evidence suggests that ferroptosis serve as a novel tumor …

Abstract Purpose of Review Conventional clinico-pathological features in melanoma
patients should be integrated with new molecular diagnostic, predictive, and prognostic …

The mouse double minute 4 (MDM4) is emerging from the shadow of its more famous
relative MDM2 and is starting to steal the limelight, largely due to its therapeutic possibilities …

The increasing incidence of skin cancer (SC) is a global health concern. The commonly
reported side effects and resistance mechanisms have imposed the pursuit for new …

The tumor suppressor protein p53 participates in the control of key biological functions such
as cell death, metabolic homeostasis and immune function, which are closely related to …

Melanoma stem cells (MSCs) are characterized by their unique cell surface proteins and
aberrant signaling pathways. These stemness properties are either in a causal or …

Chronic hyperglycaemia is a devastating factor that causes diabetes-induced damage to the
retina and kidney. However, the precise mechanism by which hyperglycaemia drives …