Background Every day the skin is constantly exposed to several harmful factors that induce
oxidative stress. When the cells are incapable to maintain the balance between antioxidant …

Unicellular eukaryotes of the genus Leishmania are collectively responsible for a
heterogeneous group of diseases known as leishmaniasis. The visceral form of …

Immune-modulating therapies have revolutionized the treatment of chronic diseases,
particularly cancer. However, their success is restricted and there is a need to identify new …

Leishmaniasis is a vector-borne disease caused by different species of protozoan parasites
of the genus Leishmania. It is a major health problem yet neglected tropical diseases, with …

Leishmaniae are obligatory intracellular protozoa in mononuclear phagocytes. They cause a
spectrum of diseases, ranging in severity from spontaneously healing skin lesions to fatal …

The skin is an organ harboring several types of immune cells that participate in innate and
adaptive immune responses. The immune system of the skin comprises both skin cells and …

In dogs with symptomatic or asymptomatic leishmaniosis, Leishmania infantum appears to
induce a mixed Th1/Th2 immune response that in the sick dog may eventually result in …

Visceral Leishmaniasis (VL) is the most fatal form of disease leishmaniasis. To date, there
are no effective prophylactic measures and therapeutics available against VL. Recently, new …

Although leishmaniases are endemic in 98 countries, they are still considered neglected
tropical diseases. Leishmaniases are characterized by the emergence of new virulent and …

We investigated the cellular basis for secretion of inflammatory cytokines in mice following
intravenous administration of adenoviral vectors (Ad). Serum inflammatory cytokines …