Delivery of drugs across the blood–brain barrier has been shown to be altered during
pathological states involving pain. Pain is a complex phenomenon involving immune and …

Objective: The authors tested the hypothesis that concentrations of the pain-transmitting
neuropeptide substance P are elevated in the CSF of patients with major depression or …

Proinflammatory cytokines, such as interleukin‐1β and tumour necrosis factor‐α, are
released by activated glial cells in the spinal cord and play a major role in pain facilitation …

The tachykinin family of vasoactive peptides comprises the neuropeptides substance P,
neurokinin A and neurokinin B, and the newly discovered endokinins and hemokinins. Their …

Ischaemic stroke, accompanied by neuroinflammation, impairs blood–brain barrier (BBB)
integrity through a complex mechanism involving activation of both RhoA/Rho …

Severe dietary Mg restriction (Mg9, 9% of recommended daily allowance [RDA], plasma
Mg= 0.25 m M) induces a proinflammatory neurogenic response in rats (substance P [SP]) …

Objective: To verify whether HIV envelope protein gp120 changes the blood-brain barrier in
vivo, as a fundamental mechanism of early central nervous system damage by HIV-1 …

We examined the hypothesis that the introduction of an inflammatory agent would augment
status epilepticus (SE)‐induced neuronal injury in the developing rat brain in the absence of …

We recently demonstrated that substance P mediates increased permeability of brain
endothelium exposed to HIV-1 gp120. To test whether substance P is involved in immune …

To test the hypothesis of an involvement of tachykinins in destabilization and hyperexcitation
of neuronal circuits, gliosis, and neuroinflammation during cerebral ischemia, we …