A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …

Eukaryotic cells have developed complex systems to regulate the production and response
to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour …

Enhancing the intracellular labile iron pool (LIP) represents a powerful, yet untapped
strategy for driving ferroptotic death of cancer cells. Here, we show that NRF2 maintains iron …

The pentose phosphate pathway (PPP) is a glucose-oxidizing pathway that runs in parallel
to upper glycolysis to produce ribose 5-phosphate and nicotinamide adenine dinucleotide …

Redox reactions are intrinsically linked to energy metabolism. Therefore, redox processes
are indispensable for organismal physiology and life itself. The term reactive oxygen species …

Reactive oxygen species (ROS) serve as cell signaling molecules generated in oxidative
metabolism and are associated with a number of human diseases. The reprogramming of …

Contingent upon concentration, reactive oxygen species (ROS) influence cancer evolution
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …

Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the
cellular defense against toxic and oxidative insults through the expression of genes involved …

Metabolic pathways and redox reactions are at the core of life. In the past decade (s),
numerous discoveries have shed light on how metabolic pathways determine the cellular …

Myopia, also known as short-sightedness or near-sightedness, is a very common condition
that typically starts in childhood. Severe forms of myopia (pathologic myopia) are associated …