Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging
K Jomova, R Raptova, SY Alomar, SH Alwasel… - Archives of …, 2023 - Springer
A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …
The role of ROS in tumour development and progression
EC Cheung, KH Vousden - Nature Reviews Cancer, 2022 - nature.com
Eukaryotic cells have developed complex systems to regulate the production and response
to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour …
to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour …
NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8
Enhancing the intracellular labile iron pool (LIP) represents a powerful, yet untapped
strategy for driving ferroptotic death of cancer cells. Here, we show that NRF2 maintains iron …
strategy for driving ferroptotic death of cancer cells. Here, we show that NRF2 maintains iron …
The pentose phosphate pathway in health and disease
The pentose phosphate pathway (PPP) is a glucose-oxidizing pathway that runs in parallel
to upper glycolysis to produce ribose 5-phosphate and nicotinamide adenine dinucleotide …
to upper glycolysis to produce ribose 5-phosphate and nicotinamide adenine dinucleotide …
Redox metabolism: ROS as specific molecular regulators of cell signaling and function
C Lennicke, HM Cochemé - Molecular Cell, 2021 - cell.com
Redox reactions are intrinsically linked to energy metabolism. Therefore, redox processes
are indispensable for organismal physiology and life itself. The term reactive oxygen species …
are indispensable for organismal physiology and life itself. The term reactive oxygen species …
[HTML][HTML] The double-edged roles of ROS in cancer prevention and therapy
Y Wang, H Qi, Y Liu, C Duan, X Liu, T Xia, D Chen… - Theranostics, 2021 - ncbi.nlm.nih.gov
Reactive oxygen species (ROS) serve as cell signaling molecules generated in oxidative
metabolism and are associated with a number of human diseases. The reprogramming of …
metabolism and are associated with a number of human diseases. The reprogramming of …
[HTML][HTML] Oxidative stress in cancer
Contingent upon concentration, reactive oxygen species (ROS) influence cancer evolution
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …
NRF2, a transcription factor for stress response and beyond
F He, X Ru, T Wen - International journal of molecular sciences, 2020 - mdpi.com
Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the
cellular defense against toxic and oxidative insults through the expression of genes involved …
cellular defense against toxic and oxidative insults through the expression of genes involved …
Redox regulation of immunometabolism
J Muri, M Kopf - Nature Reviews Immunology, 2021 - nature.com
Metabolic pathways and redox reactions are at the core of life. In the past decade (s),
numerous discoveries have shed light on how metabolic pathways determine the cellular …
numerous discoveries have shed light on how metabolic pathways determine the cellular …
Myopia
PN Baird, SM Saw, C Lanca, JA Guggenheim… - Nature reviews Disease …, 2020 - nature.com
Myopia, also known as short-sightedness or near-sightedness, is a very common condition
that typically starts in childhood. Severe forms of myopia (pathologic myopia) are associated …
that typically starts in childhood. Severe forms of myopia (pathologic myopia) are associated …