Type 1 diabetes mellitus is believed to result from destruction of the insulin-producing β-cells
in pancreatic islets that is mediated by autoimmune mechanisms. The classic view is that …

Since the discovery of interleukin-10 (IL-10) in the 1980s, a large body of work has led to its
recognition as a pleiotropic immunomodulatory cytokine that affects both the innate and …

Gold nanoparticles display unique physicochemical features, which can be useful for
therapeutic purposes. After two decades of preclinical progress, gold nanoconstructs are …

Type 1 diabetes is an autoimmune disease characterised by the destruction of insulin
producing beta cells in the pancreas. Whilst it remains unclear what the original triggering …

Microneedle systems are a rapidly growing and promising technology for delivery of drugs,
such as vaccines, small molecules, or biologics and for aesthetic skin treatment in local …

Immunotherapy using short immunogenic peptides of disease-related autoantigens restores
immune tolerance in preclinical disease models. We studied safety and mechanistic effects …

Type 1 diabetes is characterized by recognition of one or more β-cell proteins by the
immune system. The list of target antigens in this disease is ever increasing and it is …

Antigen-specific immunotherapy combats autoimmunity or allergy by reinstating
immunological tolerance to target antigens without compromising immune function …

Precision medicine has emerged as a mantra for therapeutic approaches to complex
diseases. The defining concept relies on a detailed insight into disease pathogenesis and …

Gold nanoparticles (AuNPs) have undergone significant research for their use in the
treatment of cancer. Numerous researchers have established their potent antitumor …