Acetonitrile is commonly used as an organic solvent and can also be used as an important
intermediate in organic synthesis. Its widespread use has led to the development of new …

Many studies have been carried out to find synthetic pathways to nicotinonitriles (3-
cyanopyridines) and their analogs, which has resulted in a substantial amount of knowledge …

Background Thrombosis is the pathological basis of cardiovascular and cerebrovascular
diseases, which seriously threaten human life and health. Among them, nearly half of …

A new heterogeneous nanocatalyst LDH@ 3-chloropyltrimethoxysilane@ 1, 3-
benzenedisulfonyl amine@ Cu (LDH@ TRMS@ BDSA@ Cu) was synthesized and …

Vascular endothelial growth factor receptor-2 is a dynamic target for therapeutic intervention
in various types of cancer. This study was aimed at exploring the VEGFR-2 inhibitory activity …

For the horseshoe tactic to succeed in inhibiting c-Met and Pim-1, the nicotinonitrile
derivatives (2a-n) were produced in high quantities by coupling acetyl phenylpyrazole (1) …

Seven novel azo dyes with 2-pyridone and dihydropyrimidinone moieties have been
synthesized and thoroughly characterized. The azo-hydrazone tautomerism has been …

Aim: A fragment-based design and synthesis of three novel series of aminopyridone-linked
benzimidazoles as potential anticancer candidates with significant CDK9 inhibition was …

Although a plethora of targeted anticancer small molecule drugs became available, the low
response rate and drug resistance imply the continuous need for expanding the anticancer …

Herein, we report design and synthesis of twenty-one dual PIM-1/HDAC inhibitors utilizing 3-
cyanopyridines as a novel cap moiety linked with aliphatic/aromatic linker bearing carboxylic …