Enteric viruses, particularly rotaviruses and noroviruses, are a leading cause of
gastroenteritis worldwide. Rotaviruses primarily affect young children, accounting for almost …

Vaccines are the most effective means available for preventing infectious diseases.
However, vaccine-induced immune responses are highly variable between individuals and …

In enteric viral infections, such as those with rotavirus and norovirus, individual viral particles
shed in stool are considered the optimal units of fecal-oral transmission. We reveal that …

Recent advances of rotavirus (RV) basic and applied research are reviewed. They consist of
determination of the RV particle structure and functions of structural proteins, classification …

Most pathogens access the body through the mucosal membranes. Therefore, effective
vaccines that protect at these sites are much needed. However, despite early success with …

Diarrhea caused by enteric infections is a major factor in morbidity and mortality worldwide.
An estimated 2-4 billion episodes of infectious diarrhea occur each year and are especially …

SUMMARY A vast and diverse array of microbial species displaying great phylogenic,
genomic, and metabolic diversity have colonized the gastrointestinal tract. Resident …

Diarrhoeal disease remains a major health burden worldwide. Secretory diarrhoeas are
caused by certain bacterial and viral infections, inflammatory processes, drugs and genetic …

Interferons (IFN s) are produced in response to virus infection and induce an antiviral state in
virtually all cell types. In addition to upregulating the transcription of genes that inhibit virus …

Activators of innate immunity may have the potential to combat a broad range of infectious
agents. We report that treatment with bacterial flagellin prevented rotavirus (RV) infection in …