A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …

Somlyo, Andrew P., and Avril V. Somlyo. Ca2+ Sensitivity of Smooth Muscle and Nonmuscle
Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase. Physiol Rev 83 …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

Inflammatory mediators increase vascular permeability primarily by formation of intercellular
gaps between endothelial cells of post-capillary venules. Under these conditions …

Ultrasound-driven microbubbles can trigger reversible membrane perforation
(sonoporation), open interendothelial junctions and stimulate endocytosis, thereby providing …

Endothelial permeability depends on the integrity of intercellular junctions as well as
actomyosin-based cell contractility. Rho GTPases have been implicated in signalling by …

Thrombosis associated with the pathophysiological activation of platelets and vascular cells
has brought thrombin and its receptors to the forefront of cardiovascular medicine. Thrombin …

Cardiovascular diseases, including atherothrombosis, are the leading cause of morbidity
and mortality in the United States, Europe, and the developed world. Matrix …

In addition to its established roles in the haemostatic system, thrombin is an intriguing
coagulation protease demonstrating an array of effects on endothelial cells, vascular smooth …

We recently reported the critical importance of Rac GTPase-dependent cortical actin
rearrangement in the augmentation of pulmonary endothelial cell (EC) barrier function by …