Mosquito-borne diseases, such as dengue and malaria, pose significant global health
burdens. Unfortunately, current control methods based on insecticides and environmental …

Genetic biocontrol aims to suppress or modify populations of species to protect public
health, agriculture, and biodiversity. Advancements in genome engineering technologies …

The ability to engineer gene drives (genetic elements that bias their own inheritance) has
sparked enthusiasm and concerns. Engineered gene drives could potentially be used to …

Speciation constrains the flow of genetic information between populations of sexually
reproducing organisms. Gaining control over mechanisms of speciation would enable new …

Insects have evolved highly diverse genetic sex-determination mechanisms and a relatively
balanced male to female sex ratio is generally expected. However, selection may shift the …

Advances in molecular and synthetic biology are enabling the engineering of gene drives in
insects for disease vector/pest control. Engineered gene drives (that bias their own …

As a major insect vector of multiple arboviruses, Aedes aegypti poses a significant global
health and economic burden. A number of genetic engineering tools have been exploited to …

Understanding the genetic basis of reproductive isolation and adaptive traits in natural
populations is one of the fundamental goals in evolutionary biology. Genome editing …

Abstract Engineered Genetic Incompatibility (EGI) is a method to create species-like barriers
to sexual reproduction. It has applications in pest control that mimic Sterile Insect Technique …

Genetic drive represents a fundamental evolutionary force that can exact profound change
to the genetic composition of populations by biasing allele transmission. Herein I propose …