Ultra-high-performance liquid chromatography high-resolution mass spectrometry variants for metabolomics research
Ultra-high-performance liquid chromatography high-resolution mass spectrometry (UHPLC–
HRMS) variants currently represent the best tools to tackle the challenges of complexity and …
HRMS) variants currently represent the best tools to tackle the challenges of complexity and …
The power of ion mobility-mass spectrometry for structural characterization and the study of conformational dynamics
Mass spectrometry is a vital tool for molecular characterization, and the allied technique of
ion mobility is enhancing many areas of (bio) chemical analysis. Strong synergy arises …
ion mobility is enhancing many areas of (bio) chemical analysis. Strong synergy arises …
Predicting drug metabolism: experiment and/or computation?
J Kirchmair, AH Göller, D Lang, J Kunze… - Nature reviews Drug …, 2015 - nature.com
Drug metabolism can produce metabolites with physicochemical and pharmacological
properties that differ substantially from those of the parent drug, and consequently has …
properties that differ substantially from those of the parent drug, and consequently has …
Metabolomics and lipidomics using traveling-wave ion mobility mass spectrometry
G Paglia, G Astarita - Nature protocols, 2017 - nature.com
Metabolomics and lipidomics aim to profile the wide range of metabolites and lipids that are
present in biological samples. Recently, ion mobility spectrometry (IMS) has been used to …
present in biological samples. Recently, ion mobility spectrometry (IMS) has been used to …
Ion mobility spectrometry‐mass spectrometry (IMS‐MS) of small molecules: Separating and assigning structures to ions
C Lapthorn, F Pullen… - Mass spectrometry …, 2013 - Wiley Online Library
The phenomenon of ion mobility (IM), the movement/transport of charged particles under the
influence of an electric field, was first observed in the early 20th Century and harnessed later …
influence of an electric field, was first observed in the early 20th Century and harnessed later …
Ion mobility-derived collision cross section as an additional measure for lipid fingerprinting and identification
Despite recent advances in analytical and computational chemistry, lipid identification
remains a significant challenge in lipidomics. Ion-mobility spectrometry provides an accurate …
remains a significant challenge in lipidomics. Ion-mobility spectrometry provides an accurate …
Structural characterization of drug-like compounds by ion mobility mass spectrometry: comparison of theoretical and experimentally derived nitrogen collision cross …
I Campuzano, MF Bush, CV Robinson… - Analytical …, 2012 - ACS Publications
We present the use of drug-like molecules as a traveling wave (T-wave) ion mobility (IM)
calibration sample set, covering the m/z range of 122.1–609.3, the nitrogen collision cross …
calibration sample set, covering the m/z range of 122.1–609.3, the nitrogen collision cross …
Serpentine ultralong path with extended routing (SUPER) high resolution traveling wave ion mobility-MS using structures for lossless ion manipulations
Ion mobility (IM) separations have a broad range of analytical applications, but insufficient
resolution often limits their utility. Here, we report on ion mobility separations in a structures …
resolution often limits their utility. Here, we report on ion mobility separations in a structures …
Recent developments in liquid chromatography–mass spectrometry and related techniques
M Holčapek, R Jirásko, M Lísa - Journal of Chromatography A, 2012 - Elsevier
This review summarizes the state-of-art in liquid chromatography–mass spectrometry (LC–
MS) and related techniques with the main focus on recent developments in the last decade …
MS) and related techniques with the main focus on recent developments in the last decade …
Ion mobility mass spectrometry of peptide ions: effects of drift gas and calibration strategies
MF Bush, IDG Campuzano, CV Robinson - Analytical chemistry, 2012 - ACS Publications
One difficulty in using ion mobility (IM) mass spectrometry (MS) to improve the specificity of
peptide ion assignments is that IM separations are performed using a range of pressures …
peptide ion assignments is that IM separations are performed using a range of pressures …