Ultra-high-performance liquid chromatography high-resolution mass spectrometry (UHPLC–
HRMS) variants currently represent the best tools to tackle the challenges of complexity and …

Mass spectrometry is a vital tool for molecular characterization, and the allied technique of
ion mobility is enhancing many areas of (bio) chemical analysis. Strong synergy arises …

Drug metabolism can produce metabolites with physicochemical and pharmacological
properties that differ substantially from those of the parent drug, and consequently has …

Metabolomics and lipidomics aim to profile the wide range of metabolites and lipids that are
present in biological samples. Recently, ion mobility spectrometry (IMS) has been used to …

The phenomenon of ion mobility (IM), the movement/transport of charged particles under the
influence of an electric field, was first observed in the early 20th Century and harnessed later …

Despite recent advances in analytical and computational chemistry, lipid identification
remains a significant challenge in lipidomics. Ion-mobility spectrometry provides an accurate …

We present the use of drug-like molecules as a traveling wave (T-wave) ion mobility (IM)
calibration sample set, covering the m/z range of 122.1–609.3, the nitrogen collision cross …

Ion mobility (IM) separations have a broad range of analytical applications, but insufficient
resolution often limits their utility. Here, we report on ion mobility separations in a structures …

This review summarizes the state-of-art in liquid chromatography–mass spectrometry (LC–
MS) and related techniques with the main focus on recent developments in the last decade …

One difficulty in using ion mobility (IM) mass spectrometry (MS) to improve the specificity of
peptide ion assignments is that IM separations are performed using a range of pressures …