Class BG protein-coupled receptors (GPCRs) are important targets in the treatment of
metabolic syndrome and diabetes. Although multiple structures of class B GPCRs–G protein …

Atomistic-level investigation of olfactory receptors (ORs) is a challenging task due to the
experimental/computational difficulties in the structural determination/prediction for members …

Abstract Information on the co-evolution of amino acid pairs in a protein can be used for
endeavors such as protein engineering, mutation design, and structure prediction. Here we …

Allostery, the presence of functional interactions between distant parts of proteins, is a
critical concept in the field of biochemistry and molecular biology, particularly in the context …

As a key regulator for the renin-angiotensin system, a class AG protein-coupled receptor
(GPCR), AngII type 2 receptor (AT 2 R), plays a pivotal role in the homeostasis of the …

Background G protein-coupled receptors (GPCRs) comprise a family of membrane proteins
that can be activated by a variety of external factors. The μ-opioid receptor (MOR), a class A …

Energetic properties of a protein are a major determinant of its evolutionary fitness. Using a
reconstruction algorithm, dating the reconstructed proteins and calculating the interaction …

Measuring the relative effect that any two sequence positions have on each other may
improve protein design or help better interpret coding variants. Current approaches use …