Mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs including
embryogenesis, proliferation, differentiation and apoptosis based on cues derived from the …

Mitogen-activated protein kinases (MAPKs) are members of a dynamic protein kinase
network through which diverse stimuli regulate the spatio-temporal activities of complex …

Introduction Discrimination of rheumatoid arthritis (RA) patients from patients with other
inflammatory or degenerative joint diseases or healthy individuals purely on the basis of …

Elevated circulating levels of chemokines have been reported in patients with dengue fever
and are proposed to contribute to the pathogenesis of dengue disease. To establish in vitro …

Abstract Fos-related antigen-2 (Fra-2) belongs to the activator protein 1 (AP-1) family of
transcription factors and is involved in a broad variety of cellular processes, such as …

Epithelial-to-mesenchymal transition (EMT) is a collection of events that allows the
conversion of adherent epithelial cells, tightly bound to each other within an organized …

MAP3K1 is a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family
of serine/threonine kinases. MAP3K1 regulates JNK activation and is unique among human …

Chronic inflammatory disorders, such as rheumatoid arthritis, are often accompanied by
systemic bone loss, which is thought to occur through inflammatory cytokine-mediated …

MAPKs are members of a three-kinase phosphorelay system composed of the MAPK, MAPK
kinase (MKK) and MAPK kinase kinase (MKKK). MKKKs phosphorylate and activate MKKs …

The transcription factor ΔFosB (Delta FosB) accumulates in a region‐specific manner in the
brain during chronic exposure to stress, drugs of abuse or other chronic stimuli. Once …