For many years, the dogma has been that insulin resistance precedes the development of
hyperinsulinemia. However, recent data suggest a reverse order and place …

Alzheimer's disease (AD) is the most common form of dementia in the elderly followed by
vascular dementia. In addition to clinically diagnosed dementia, cognitive dysfunction has …

The incidence of diabetes, as a metabolic disease characterized by high blood sugar levels,
is increasing every year. The predominantly western medicine treatment is associated with …

Human Islet amyloid polypeptide (hIAPP) from pancreatic β cells in the islet of Langerhans
has different physiological functions including inhibiting the release of insulin and glucagon …

Plasma insulin clearance is an important determinant of plasma insulin concentration. In this
review, we provide an overview of the factors that regulate insulin removal from plasma and …

More than seven decades have passed since the discovery of a proteolytic activity within
crude tissue extracts that would become known as insulin-degrading enzyme (IDE) …

Purpose This review aims to provide a precise perceptive of the insulin-degrading enzyme
(IDE) and its relationship to type 2 diabetes (T2D), Alzheimer's disease (AD), obesity, and …

In the 1950's, Dr. I. Arthur Mirsky first recognized the possible importance of insulin
degradation changes to the pathogenesis of type 2 diabetes. While this mechanism was …

The insulin-degrading enzyme (IDE) is an evolutionarily conserved protease implicated in
the degradation of insulin and amyloidogenic peptides. Most of the biochemical and …

Polycystic ovary syndrome (PCOS) is a very frequent disease that affects reproductive ability
and menstrual regularity. Other than the criteria established at the Rotterdam consensus, in …