Abstract Dopamine (DA, 3-hydroxytyramine) is a member of the catecholamine family and is
classically characterized according to its role in the central nervous system as a …

Vitamin C also known as L-ascorbic acid is a nutrient naturally occurring in many fruits and
vegetables and widely known for its potent antioxidant activity. Several studies have …

Targeted therapies and immunotherapy have brought substantial benefits to patients with
melanoma. However, brain metastases remain the biggest threat to the survival and quality …

Monoclonal antibodies targeting the programmed-death 1 (PD-1) immune checkpoint or its
ligand PD-L1 have significantly improved the treatment of cancers but more efficient drugs …

The brain–gut axis, a bidirectional network between the central and enteric nervous system,
plays a critical role in modulating the gastrointestinal tract function and homeostasis …

Purpose Despite efforts in developing effective therapeutic strategies, colorectal cancer
(CRC) remains one of the most prevalent and lethal neoplasms. Repurposing approved …

Systemic analysis of available large-scale biological/biomedical data is critical for studying
biological mechanisms, and developing novel and effective treatment approaches against …

Over a century ago, the phenothiazine dye, methylene blue, was discovered to have both
antipsychotic and anti-cancer effects. In the 20th-century, the first phenothiazine …

Immune checkpoint inhibitors (ICIs), including anti-programmed cell death-1/anti-
programmed cell death ligand-1 (anti-PD-1/PD-L1) therapy, have elicited impressive clinical …

Background. Immune checkpoint inhibitor therapy targeting antiprogrammed cell death‐1
(anti‐PD‐1) or its ligand (anti‐PD‐L1) is effective in the treatment of some hepatocellular …