Eukaryotic cells create internal order by using protein motors to transport molecules and
organelles along cytoskeletal tracks. Recent genomic and functional studies suggest that …

The myosin family of actin filament-based molecular motors consists of at least 20
structurally and functionally distinct classes. The human genome contains nearly 40 myosin …

Myosin V is a dimeric molecular motor that moves processively on actin, with the center of
mass moving∼ 37 nanometers for each adenosine triphosphate hydrolyzed. We have …

Human antibody 2G12 neutralizes a broad range of human immunodeficiency virus type 1
(HIV-1) isolates by binding an unusually dense cluster of carbohydrate moieties on the …

Mitochondria are dynamic organelles in cells. The control of mitochondrial motility by
signaling mechanisms and the significance of rapid changes in motility remains elusive. In …

Melanosomes are morphologically and functionally unique organelles within which melanin
pigments are synthesized and stored. Melanosomes share some characteristics with …

Myosin Va is associated with discrete vesicle populations in a number of cell types, but little
is known of the function of myosin Vb. Yeast two-hybrid screening of a rabbit parietal cell …

▪ Abstract Cell polarity, as reflected by polarized growth and organelle segregation during
cell division in yeast, appears to follow a simple hierarchy. On the basis of physical cues …

Functional denervation is a hallmark of aging sarcopenia as well as of muscular dystrophy. It
is thought to be a major factor reducing skeletal muscle mass, particularly in the case of …

Myosin-V is a molecular motor that moves processively along its actin track. We have used a
feedback-enhanced optical trap to examine the stepping kinetics of this movement. By …