The Notch signaling pathway is conserved among mammalian species and controls
proliferation, differentiation, and cell death in many organs throughout the body including the …

Developmental signalling pathways such as Wnt/β-catenin, Notch and Sonic hedgehog play
a central role in nearly all the stages of neuronal development. The term 'embryonic'might …

The sirtuins are NAD+-dependent protein deacetylases and/or ADP-ribosyltransferases that
play roles in metabolic homeostasis, stress response and potentially aging. This enzyme …

Abstract Di‐(2‐ethylhexyl) phthalate (DEHP) is an environmental endocrine disruptor widely
used in China that is harmful to the male reproductive system. Many studies have shown that …

Objective To investigate microRNA (miRNA) expression profiles in the seminal plasma of
nonobstructive azoospermia (NOA) patients with different histopathologic patterns and …

Epidemiological investigation suggested that the use of acetaminophen during pregnancy
may cause offspring testicular dysplasia, but no systematic study has been conducted. In this …

In a previous study we identified active Notch signaling in key cellular events occurring at
adult spermatogenesis. In this study, we evaluated the function of Notch signaling in …

Background Notch signaling pathway is involved in contact‐dependent communication
between the cells of seminiferous epithelium, and its proper activity is important for …

Leydig cells, located within the interstitial compartment of the testis, are major contributors of
androgen synthesis and secretion, which play an important role in testis development …

Background Mammalian early embryo development requires a well-orchestrated interplay of
cell signaling pathways. Notch is a major regulatory pathway involved in cell-fate …